Obesity and eating behavior from the perspective of twin and genetic research
K Silventoinen, H Konttinen - Neuroscience & biobehavioral reviews, 2020 - Elsevier
Obesity has dramatically increased during the last decades and is currently one of the most
serious global health problems. We present a hypothesis that obesity is a neuro-behavioral …
serious global health problems. We present a hypothesis that obesity is a neuro-behavioral …
Population-specific and trans-ancestry genome-wide analyses identify distinct and shared genetic risk loci for coronary artery disease
To elucidate the genetics of coronary artery disease (CAD) in the Japanese population, we
conducted a large-scale genome-wide association study of 168,228 individuals of Japanese …
conducted a large-scale genome-wide association study of 168,228 individuals of Japanese …
Recent efforts to dissect the genetic basis of alcohol use and abuse
Alcohol use disorder (AUD) is defined by several symptom criteria, which can be dissected
further at the genetic level. Over the past several years, our understanding of the genetic …
further at the genetic level. Over the past several years, our understanding of the genetic …
Identification of type 2 diabetes loci in 433,540 East Asian individuals
Meta-analyses of genome-wide association studies (GWAS) have identified more than 240
loci that are associated with type 2 diabetes (T2D),; however, most of these loci have been …
loci that are associated with type 2 diabetes (T2D),; however, most of these loci have been …
Improving the trans-ancestry portability of polygenic risk scores by prioritizing variants in predicted cell-type-specific regulatory elements
Poor trans-ancestry portability of polygenic risk scores is a consequence of Eurocentric
genetic studies and limited knowledge of shared causal variants. Leveraging regulatory …
genetic studies and limited knowledge of shared causal variants. Leveraging regulatory …
The interplay between host genetics and the gut microbiome reveals common and distinct microbiome features for complex human diseases
Background Interest in the interplay between host genetics and the gut microbiome in
complex human diseases is increasing, with prior evidence mainly being derived from …
complex human diseases is increasing, with prior evidence mainly being derived from …
Ancestry deconvolution and partial polygenic score can improve susceptibility predictions in recently admixed individuals
Abstract Polygenic Scores (PSs) describe the genetic component of an individual's
quantitative phenotype or their susceptibility to diseases with a genetic basis. Currently, PSs …
quantitative phenotype or their susceptibility to diseases with a genetic basis. Currently, PSs …
Genetic mapping of etiologic brain cell types for obesity
PN Timshel, JJ Thompson, TH Pers - Elife, 2020 - elifesciences.org
The underlying cell types mediating predisposition to obesity remain largely obscure. Here,
we integrated recently published single-cell RNA-sequencing (scRNA-seq) data from 727 …
we integrated recently published single-cell RNA-sequencing (scRNA-seq) data from 727 …
The Parkinson's disease genome‐wide association study locus browser
FP Grenn, JJ Kim, MB Makarious, H Iwaki… - Movement …, 2020 - Wiley Online Library
Background Parkinson's disease (PD) is a neurodegenerative disease with an often
complex component identifiable by genome‐wide association studies. The most recent large …
complex component identifiable by genome‐wide association studies. The most recent large …
[PDF][PDF] Accurate and scalable construction of polygenic scores in large biobank data sets
Accurate construction of polygenic scores (PGS) can enable early diagnosis of diseases and
facilitate the development of personalized medicine. Accurate PGS construction requires …
facilitate the development of personalized medicine. Accurate PGS construction requires …