The role of clopidogrel in 2020: a reappraisal

G Patti, G Micieli, C Cimminiello… - Cardiovascular …, 2020 - Wiley Online Library
Antiplatelet therapy is the mainstay of treatment and secondary prevention of cardiovascular
disease (CVD), including acute coronary syndrome (ACS), transient ischemic attack (TIA) or …

Derivation, validation, and prognostic utility of a prediction rule for nonresponse to clopidogrel: the ABCD-GENE score

DJ Angiolillo, D Capodanno, N Danchin… - Cardiovascular …, 2020 - jacc.org
Objectives The aim of this study was to develop a risk score integrating cytochrome P450
2C19 loss-of-function genotypes with clinical risk factors influencing clopidogrel response …

Outcome of intracranial flow diversion according to the antiplatelet regimen used: a systematic review and meta-analysis

A Podlasek, AA Al Sultan, Z Assis, N Kashani… - Journal of …, 2020 - jnis.bmj.com
Background Thromboembolic complications are not uncommon in patients undergoing
neurointerventional procedures. The use of flow diverting stents is associated with higher …

Relationship between platelet reactivity and ischemic and bleeding events after percutaneous coronary intervention in East Asian patients: 1‐year results of the …

M Nakamura, K Kadota, A Takahashi… - Journal of the …, 2020 - Am Heart Assoc
Background The balance between ischemic and bleeding events and their association with
platelet reactivity in patients receiving antiplatelet therapy after percutaneous coronary …

Personalized antiplatelet therapy guided by a novel detection of platelet aggregation function in stable coronary artery disease patients undergoing percutaneous …

YY Zheng, TT Wu, Y Yang, XG Hou… - European Heart …, 2020 - academic.oup.com
Aims A number of studies have attempted to demonstrate the benefits associated with
personalized antiplatelet therapy guided by platelet function testing, which has led to …

Routine CYP2C19 Genotyping to Adjust Thienopyridine Treatment After Primary PCI for STEMI: Results of the GIANT Study

JS Hulot, B Chevalier, L Belle, G Cayla… - Cardiovascular …, 2020 - jacc.org
Objectives The aim of this study was to evaluate prospectively the clinical impact of routine
transmission of CYP2C19 genotype in the management of acute ST-segment elevation …

[HTML][HTML] Platelet inhibition in acute coronary syndrome and percutaneous coronary intervention: insights from the past and present

DA Gorog, T Geisler - Thrombosis and haemostasis, 2020 - thieme-connect.com
Platelet activation and aggregation have a pivotal role in arterial thrombosis and in the
pathogenesis of both acute coronary syndromes (ACS) and in the thrombotic complications …

[HTML][HTML] High glycated albumin is an independent predictor of low response to clopidogrel in ACS patients: a cross-sectional study

X Zhao, Q Li, C Tu, Y Zeng, Y Ye - Cardiovascular Diabetology, 2020 - Springer
Background Glycated albumin (GA) is a marker of short-term glycemic control and is strongly
associated with the occurrence of diabetes. Previous studies have shown an association …

Platelet function/reactivity testing and prediction of risk of recurrent vascular events and outcomes after TIA or ischaemic stroke: systematic review and meta-analysis

ST Lim, V Thijs, SJX Murphy, I Fernandez-Cadenas… - Journal of …, 2020 - Springer
Background The prevalence of ex vivo 'high on-treatment platelet reactivity (HTPR)'and its
relationship with recurrent vascular events/outcomes in patients with ischaemic …

[HTML][HTML] Platelet function test use for patients with coronary artery disease in the early 2020s

P Fontana, M Roffi, JL Reny - Journal of clinical medicine, 2020 - mdpi.com
In the field of antithrombotics, precision medicine is of particular interest, as it may lower the
incidence of potentially life-threatening side effects. Indeed, antiplatelet drugs such as …