A comprehensive overview of oncogenic pathways in human cancer

F Li, T Wu, Y Xu, Q Dong, J Xiao, Y Xu… - Briefings in …, 2020 - academic.oup.com
Alterations of biological pathways can lead to oncogenesis. An overview of these oncogenic
pathways would be highly valuable for researchers to reveal the pathogenic mechanism and …

LnCeVar: a comprehensive database of genomic variations that disturb ceRNA network regulation

P Wang, X Li, Y Gao, Q Guo, S Ning… - Nucleic acids …, 2020 - academic.oup.com
Abstract LnCeVar (http://www. bio-bigdata. net/LnCeVar/) is a comprehensive database that
aims to provide genomic variations that disturb lncRNA-associated competing endogenous …

Dissecting expression profiles of gastric precancerous lesions and early gastric cancer to explore crucial molecules in intestinal‐type gastric cancer tumorigenesis

Y Zhang, X Wu, C Zhang, J Wang, G Fei… - The Journal of …, 2020 - Wiley Online Library
Intestinal‐type gastric cancer (IGC) has a clear and multistep histological evolution. No
studies have comprehensively explored gastric tumorigenesis from inflammation through …

Complex impact of DNA methylation on transcriptional dysregulation across 22 human cancer types

Z Wang, J Yin, W Zhou, J Bai, Y Xie, K Xu… - Nucleic Acids …, 2020 - academic.oup.com
Accumulating evidence has demonstrated that transcriptional regulation is affected by DNA
methylation. Understanding the perturbation of DNA methylation-mediated regulation …

Omics analysis of educated platelets in cancer and benign disease of the pancreas

G Mantini, LL Meijer, I Glogovitis, SGJG In 't Veld… - Cancers, 2020 - mdpi.com
Simple Summary Tumor cells are known to produce and secrete pro-coagulants that recruit
blood particles such as platelets, inducing hypercoagulability. However, platelets can also …

MicroRNA-574-5p directly targets FOXN3 to mediate thyroid cancer progression via Wnt/β-catenin signaling pathway

ZJ Zhang, Q Xiao, XY Li - Pathology-Research and Practice, 2020 - Elsevier
Objective Thyroid cancer is the most common endocrine tumor. A large number of thyroid
cancer-related miRNAs have been studied and identified. However, the detailed roles of …

Functional analysis of miR-767-5p during the progression of hepatocellular carcinoma and the clinical relevance of its dysregulation

L Zhang, Z Geng, Y Wan, F Meng, X Meng… - Histochemistry and Cell …, 2020 - Springer
Aberrant microRNA (miRNA) expression is a central hallmark of hepatocellular carcinoma
(HCC) and identification of the mechanisms underlying the miRNA actions should provide …

Functional classification of prostate cancer‑associated miRNAs through CRISPR/Cas9‑mediated gene knockout

FN Jiang, YX Liang, W Wei… - Molecular …, 2020 - spandidos-publications.com
The aim of the present study was to use the clustered regularly interspaced short
palindromic repeats (CRISPR) and CRISPR‑associated (Cas) 9‑mediated gene knockout …

Identification and comprehensive characterization of lncRNAs with copy number variations and their driving transcriptional perturbed subpathways reveal functional …

Y Xu, T Wu, F Li, Q Dong, J Wang… - Briefings in …, 2020 - academic.oup.com
Numerous studies have shown that copy number variation (CNV) in lncRNA regions play
critical roles in the initiation and progression of cancer. However, our knowledge about their …

Dysregulated lncRNA-miRNA-mRNA network reveals patient survival-associated modules and RNA binding proteins in invasive breast carcinoma

Y Dong, Y Xiao, Q Shi, C Jiang - Frontiers in genetics, 2020 - frontiersin.org
Breast cancer is the most common cancer in women, but few biomarkers are effective in
clinic. Previous studies have shown the important roles of non-coding RNAs in diagnosis …