Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
INTRODUCTION Clinical outcomes of human severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection range from silent infection to lethal coronavirus …
coronavirus 2 (SARS-CoV-2) infection range from silent infection to lethal coronavirus …
Context is key: delineating the unique functions of IFNα and IFNβ in disease
LE Fox, MC Locke, DJ Lenschow - Frontiers in immunology, 2020 - frontiersin.org
Type I interferons (IFNs) are critical effector cytokines of the immune system and were
originally known for their important role in protecting against viral infections; however, they …
originally known for their important role in protecting against viral infections; however, they …
Structural integrity with functional plasticity: What type I IFN receptor polymorphisms reveal
NA de Weerd, JP Vivian, SS Lim… - Journal of Leucocyte …, 2020 - academic.oup.com
The type I IFNs activate an array of signaling pathways, which are initiated after IFNs bind
their cognate receptors, IFNα/β receptor (IFNAR) 1 and IFNAR2. These signals contribute to …
their cognate receptors, IFNα/β receptor (IFNAR) 1 and IFNAR2. These signals contribute to …
Illuminating host-mycobacterial interactions with genome-wide CRISPR knockout and CRISPRi screens
Existing antibiotics are inadequate to defeat tuberculosis (TB), a leading cause of death
worldwide. We sought potential targets for host-directed therapies (HDTs) by investigating …
worldwide. We sought potential targets for host-directed therapies (HDTs) by investigating …
Pulmonary mucosal immunity mediated through CpG provides adequate protection against pulmonary Mycobacterium tuberculosis infection in the mouse model. A …
A Troy, SC Esparza-Gonzalez, A Bartek, E Creissen… - Tuberculosis, 2020 - Elsevier
Abstract Toll-Like Receptor (TLR) 9 stimulation is required for induction of potent immune
responses against pathogen invasion. The use of unmethylated CpG as adjuvants in …
responses against pathogen invasion. The use of unmethylated CpG as adjuvants in …
Identification of potential biomarkers and related transcription factors in peripheral blood of tuberculosis patients
L Xie, X Chao, T Teng, Q Li, J Xie - International journal of environmental …, 2020 - mdpi.com
Tuberculosis (TB), one major threat to humans, can infect one third of the worldwide
population, and cause more than one million deaths each year. This study aimed to identify …
population, and cause more than one million deaths each year. This study aimed to identify …
Functional remodeling of lysosomes by type I interferon modifies host defense
H Zhang, A Zoued, X Liu, B Sit, MK Waldor - bioRxiv, 2020 - biorxiv.org
Organelle remodeling is critical for cellular homeostasis, but host factors that control
organelle function during microbial infection remain largely uncharacterized. Here, a …
organelle function during microbial infection remain largely uncharacterized. Here, a …
Illuminating host-mycobacterial interactions with functional genomic screening to inhibit mycobacterial pathogenesis
Existing antibiotics are inadequate to defeat tuberculosis (TB), a leading cause of death
worldwide. We sought potential targets for host-directed therapies (HDTs) by investigating …
worldwide. We sought potential targets for host-directed therapies (HDTs) by investigating …