Challenges in researching the immune pathways between early life adversity and psychopathology

B Reid, A Danese - Development and psychopathology, 2020 - cambridge.org
Exposure to childhood adversity is a critical risk factor for the development of
psychopathology. A growing field of research examines how exposure to childhood …

Neuroimmune mechanisms and sex/gender-dependent effects in the pathophysiology of mental disorders

AG Kokkosis, SE Tsirka - Journal of Pharmacology and Experimental …, 2020 - ASPET
Innate and adaptive immune mechanisms have emerged as critical regulators of CNS
homeostasis and mental health. A plethora of immunologic factors have been reported to …

Psychology: A giant with feet of clay

A Zagaria, A Ando', A Zennaro - Integrative Psychological and Behavioral …, 2020 - Springer
The aim of the current study has been to highlight the theoretical precariousness of
Psychology. The theoretical precariousness has been evidenced through a review of …

[PDF][PDF] Inflammation, reward circuitry and symptoms of anhedonia and PTSD in trauma-exposed women

ND Mehta, JS Stevens, Z Li, CF Gillespie… - Social Cognitive and …, 2020 - academic.oup.com
Trauma exposure is associated with increased inflammatory biomarkers (eg C-reactive
protein [CRP] and cytokines), and inflammation has been shown to impact corticostriatal …

Social bonds do not mediate the relationship between early adversity and adult glucocorticoids in wild baboons

S Rosenbaum, S Zeng, FA Campos… - Proceedings of the …, 2020 - National Acad Sciences
In humans and other animals, harsh conditions in early life can have profound effects on
adult physiology, including the stress response. This relationship may be mediated by a lack …

Prenatal and childhood adverse life events, inflammation and depressive symptoms across adolescence

E Flouri, M Francesconi, E Midouhas… - Journal of affective …, 2020 - Elsevier
Background No study has investigated the role of inflammation in explaining the association
between early exposures to adverse life events and depressive symptoms in adolescence …

The unique nature of depression and anxiety among college students with adverse childhood experiences

T Watt, N Ceballos, S Kim, X Pan, S Sharma - Journal of child & …, 2020 - Springer
It is well established that adverse childhood experiences (ACEs) contribute to the
development of mental disorders in adulthood. However, less is known about how childhood …

[HTML][HTML] Adverse childhood experiences and early life inflammation in the Avon longitudinal study of parents and children

RE Lacey, M Bartley, M Kelly-Irving… - …, 2020 - Elsevier
Abstract Background Adverse childhood experiences (ACEs) have been associated with
poorer health across the life course. Previous studies have used cumulative risk scores …

[HTML][HTML] Transcutaneous vagal nerve stimulation blocks stress-induced activation of interleukin-6 and interferon-γ in posttraumatic stress disorder: a double-blind …

JD Bremner, NZ Gurel, Y Jiao, MT Wittbrodt… - Brain, Behavior, & …, 2020 - Elsevier
Posttraumatic stress disorder (PTSD) is a highly disabling condition associated with
alterations in multiple neurobiological systems, including increases in inflammatory function …

Do documented records and retrospective reports of childhood maltreatment similarly predict chronic inflammation?

M Osborn, CS Widom - Psychological medicine, 2020 - cambridge.org
BackgroundChildhood adversities have been associated with chronic inflammation and risk
for cardiovascular disease. With some exceptions, existing knowledge of this relationship is …