Nepetin, a natural compound from Inulae flos, suppresses degranulation and eicosanoid generation through PLCγ1 and Akt signaling pathways in mast cells

N Ji, SG Kim, HH Park, E Lee, YJ Lee, M Jin… - Archives of pharmacal …, 2020 - Springer
Nepetin derived from the flowers of Inula japonica, Inulae flos, has been reported to exert
several biological activities, including anti-inflammatory responses. In this study, we …

Functional role of phosphatidylcholine-specific phospholipase C in regulating leukotriene synthesis and degranulation in human eosinophils

A Sano, H Sano, T Iwanaga, Y Tohda - European Journal of Pharmacology, 2020 - Elsevier
Phosphatidylinositol-specific phospholipase C (PI-PLC) and cytosolic phospholipase A 2
(cPLA 2) regulate both eosinophil degranulation and leukotriene (LT) synthesis via PI-PLC …