Laboratory diagnosis of coronavirus disease-2019 (COVID-19)

C Li, C Zhao, J Bao, B Tang, Y Wang, B Gu - Clinica Chimica Acta, 2020 - Elsevier
Abstract The outbreak of Coronavirus Disease-2019 (COVID-19) caused by Severe Acute
Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has threatened health worldwide. As of …

COVID‐19 clinical diagnostics and testing technology

CH Chau, JD Strope, WD Figg - Pharmacotherapy: The Journal …, 2020 - Wiley Online Library
Given the global nature of the coronavirus disease 2019 (COVID‐19) pandemic, the need
for disease detection and expanding testing capacity remains critical priorities. This review …

[HTML][HTML] Measurement of SARS-CoV-2 RNA in wastewater tracks community infection dynamics

J Peccia, A Zulli, DE Brackney, ND Grubaugh… - Nature …, 2020 - nature.com
We measured severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA
concentrations in primary sewage sludge in the New Haven, Connecticut, USA, metropolitan …

[HTML][HTML] Longitudinal analyses reveal immunological misfiring in severe COVID-19

C Lucas, P Wong, J Klein, TBR Castro, J Silva… - Nature, 2020 - nature.com
Recent studies have provided insights into the pathogenesis of coronavirus disease 2019
(COVID-19),,–. However, the longitudinal immunological correlates of disease outcome …

A colorimetric RT-LAMP assay and LAMP-sequencing for detecting SARS-CoV-2 RNA in clinical samples

VL Dao Thi, K Herbst, K Boerner, M Meurer… - Science translational …, 2020 - science.org
The coronavirus disease 2019 (COVID-19) pandemic caused by the SARS-CoV-2 (severe
acute respiratory syndrome coronavirus 2) coronavirus is a major public health challenge …

[HTML][HTML] Clinical validation of a Cas13-based assay for the detection of SARS-CoV-2 RNA

M Patchsung, K Jantarug, A Pattama… - Nature biomedical …, 2020 - nature.com
Nucleic acid detection by isothermal amplification and the collateral cleavage of reporter
molecules by CRISPR-associated enzymes is a promising alternative to quantitative PCR …

[HTML][HTML] Sex differences in immune responses that underlie COVID-19 disease outcomes

T Takahashi, MK Ellingson, P Wong, B Israelow… - Nature, 2020 - nature.com
There is increasing evidence that coronavirus disease 2019 (COVID-19) produces more
severe symptoms and higher mortality among men than among women,,,–. However …

First confirmed detection of SARS-CoV-2 in untreated wastewater in Australia: a proof of concept for the wastewater surveillance of COVID-19 in the community

W Ahmed, N Angel, J Edson, K Bibby, A Bivins… - Science of the Total …, 2020 - Elsevier
Abstract Infection with SARS-CoV-2, the etiologic agent of the ongoing COVID-19 pandemic,
is accompanied by the shedding of the virus in stool. Therefore, the quantification of SARS …

SARS-CoV-2 RNA in wastewater anticipated COVID-19 occurrence in a low prevalence area

W Randazzo, P Truchado, E Cuevas-Ferrando… - Water research, 2020 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused more than
200,000 reported COVID-19 cases in Spain resulting in more than 20,800 deaths as of April …

[HTML][HTML] COVID-19 surveillance in Southeastern Virginia using wastewater-based epidemiology

R Gonzalez, K Curtis, A Bivins, K Bibby, MH Weir… - Water research, 2020 - Elsevier
Wastewater-based epidemiology (WBE) has been used to analyze markers in wastewater
treatment plant (WWTP) influent to characterize emerging chemicals, drug use patterns, or …