Uromodulin (Tamm–Horsfall protein): Guardian of urinary and systemic homeostasis
R Micanovic, K LaFavers, PS Garimella… - Nephrology Dialysis …, 2020 - academic.oup.com
Biology has taught us that a protein as abundantly made and conserved among species as
Tamm–Horsfall protein (THP or uromodulin) cannot just be a waste product serving no …
Tamm–Horsfall protein (THP or uromodulin) cannot just be a waste product serving no …
It takes two to tango: the role of dysregulated metabolism and inflammation in kidney disease development
Acute kidney injury is a major contributor of chronic kidney disease development. The
pathogenesis of acute kidney injury and chronic kidney disease shows significant …
pathogenesis of acute kidney injury and chronic kidney disease shows significant …
[HTML][HTML] Fluid-electrolyte homeostasis requires histone deacetylase function
KA Hyndman, JS Speed, LD Mendoza, JM Allan… - JCI insight, 2020 - ncbi.nlm.nih.gov
Histone deacetylase (HDAC) enzymes regulate transcription through epigenetic
modification of chromatin structure, but their specific functions in the kidney remain elusive …
modification of chromatin structure, but their specific functions in the kidney remain elusive …
Expression of Acsm2, a kidney-specific gene, parallels the function and maturation of proximal tubular cells
H Watanabe, RL Paxton, MR Tolerico… - American Journal …, 2020 - journals.physiology.org
The acyl-CoA synthetase medium-chain family member 2 (Acsm2) gene was first identified
and cloned by our group as a kidney-specific “KS” gene. However, its expression pattern …
and cloned by our group as a kidney-specific “KS” gene. However, its expression pattern …
A summary of recent updates on the genetic determinants of depression
Depression is one of the most prevalent, disabling, and costly mental health conditions
worldwide. One promising avenue for preventing depression and informing its clinical …
worldwide. One promising avenue for preventing depression and informing its clinical …
Role of Uromodulin as a Predictor of Decline in Renal Function
R Praba - 2020 - repository-tnmgrmu.ac.in
BACKGROUND: Uromodulin is a 95 KD protein. It is synthesised by the thick ascending limb
and the distal tubule cells of kidney. It is an abundant protein excreted in urine of healthy …
and the distal tubule cells of kidney. It is an abundant protein excreted in urine of healthy …