Discriminating between negative cooperativity and ligand binding to independent sites using pre-equilibrium properties of binding curves
F Sevlever, JP Di Bella, AC Ventura - PLOS Computational …, 2020 - journals.plos.org
Negative cooperativity is a phenomenon in which the binding of a first ligand or substrate
molecule decreases the rate of subsequent binding. This definition is not exclusive to ligand …
molecule decreases the rate of subsequent binding. This definition is not exclusive to ligand …
Optimal Experimental Design Applied to Models of Microbial Gene Regulation
N Braniff - 2020 - uwspace.uwaterloo.ca
Microbial gene expression is a comparatively well understood process, but regulatory
interactions between genes can give rise to complicated behaviours. Regulatory networks …
interactions between genes can give rise to complicated behaviours. Regulatory networks …
Model-driven experimental design identifies counter-acting feedback regulation in the osmotic stress response of yeast
SK Suzuki, B Errede, HG Dohlman, TC Elston - BioRxiv, 2020 - biorxiv.org
Cells rely on mitogen-activated protein kinases (MAPKs) to survive environmental stress. In
yeast, activation of the MAPK Hog1 is known to mediate the response to high osmotic …
yeast, activation of the MAPK Hog1 is known to mediate the response to high osmotic …
Algorithms for regulatory network inference and experiment planning in systems biology
A Pratapa - 2020 - vtechworks.lib.vt.edu
I present novel solutions to two different classes of computational problems that arise in the
study of complex cellular processes. The first problem arises in the context of planning large …
study of complex cellular processes. The first problem arises in the context of planning large …