A disinhibitory nigra-parafascicular pathway amplifies seizure in temporal lobe epilepsy
The precise circuit of the substantia nigra pars reticulata (SNr) involved in temporal lobe
epilepsy (TLE) is still unclear. Here we found that optogenetic or chemogenetic activation of …
epilepsy (TLE) is still unclear. Here we found that optogenetic or chemogenetic activation of …
Direct septum-hippocampus cholinergic circuit attenuates seizure through driving somatostatin inhibition
Background Previous studies indicated the involvement of cholinergic neurons in seizure;
however, the specific role of the medial septum (MS)-hippocampus cholinergic circuit in …
however, the specific role of the medial septum (MS)-hippocampus cholinergic circuit in …
Pharmaco‐genetic inhibition of pyramidal neurons retards hippocampal kindling‐induced epileptogenesis
LY Chen, J Liang, F Fei, YP Ruan… - CNS neuroscience & …, 2020 - Wiley Online Library
Aims Pharmaco‐genetics emerges as a new promising approach for epileptic seizures.
Whether it can modulate epileptogenesis is still unknown. Methods Here, parvalbumin …
Whether it can modulate epileptogenesis is still unknown. Methods Here, parvalbumin …