Tools to map target genes of bacterial two‐component system response regulators

L Rajeev, ME Garber… - Environmental …, 2020 - Wiley Online Library
Studies on bacterial physiology are incomplete without knowledge of the signalling and
regulatory systems that a bacterium uses to sense and respond to its environment. Two …

Revealing 29 sets of independently modulated genes in Staphylococcus aureus, their regulators, and role in key physiological response

S Poudel, H Tsunemoto, Y Seif… - Proceedings of the …, 2020 - National Acad Sciences
The ability of Staphylococcus aureus to infect many different tissue sites is enabled, in part,
by its transcriptional regulatory network (TRN) that coordinates its gene expression to …

Drivers and sites of diversity in the DNA adenine methylomes of 93 Mycobacterium tuberculosis complex clinical isolates

SJ Modlin, D Conkle-Gutierrez, C Kim, SN Mitchell… - Elife, 2020 - elifesciences.org
This study assembles DNA adenine methylomes for 93 Mycobacterium tuberculosis
complex (MTBC) isolates from seven lineages paired with fully-annotated, finished, de novo …

CoryneRegNet 7, the reference database and analysis platform for corynebacterial gene regulatory networks

MTD Parise, D Parise, RB Kato, JK Pauling, A Tauch… - Scientific data, 2020 - nature.com
We present the newest version of CoryneRegNet, the reference database for
corynebacterial regulatory interactions, available at www. exbio. wzw. tum. de/coryneregnet …

[PDF][PDF] Intricate genetic programs controlling dormancy in Mycobacterium tuberculosis

EJR Peterson, AA Abidi, ML Arrieta-Ortiz, B Aguilar… - Cell reports, 2020 - cell.com
Mycobacterium tuberculosis (MTB) displays the remarkable ability to transition in and out of
dormancy, a hallmark of the pathogen's capacity to evade the immune system and exploit …

Edge-based analysis of networks: curvatures of graphs and hypergraphs

M Eidi, A Farzam, W Leal, A Samal, J Jost - Theory in biosciences, 2020 - Springer
The relations, rather than the elements, constitute the structure of networks. We therefore
develop a systematic approach to the analysis of networks, modelled as graphs or …

Computational approaches in epitope design using DNA binding proteins as vaccine candidate in Mycobacterium tuberculosis

N Singhvi, Y Singh, P Shukla - Infection, Genetics and Evolution, 2020 - Elsevier
Mycobacterium tuberculosis (Mtb) is a successful pathogen in the history of mankind. A high
rate of mortality and morbidity raises the need for vaccine development. Mechanism of …

Depletion of the DarG antitoxin in Mycobacterium tuberculosis triggers the DNA‐damage response and leads to cell death

A Zaveri, R Wang, L Botella, R Sharma… - Molecular …, 2020 - Wiley Online Library
Of the~ 80 putative toxin‐antitoxin (TA) modules encoded by the bacterial pathogen
Mycobacterium tuberculosis (Mtb), three contain antitoxins essential for bacterial viability …

EspM is a conserved transcription factor that regulates gene expression in response to the ESX-1 system

KG Sanchez, MJ Ferrell, AE Chirakos, KR Nicholson… - MBio, 2020 - Am Soc Microbiol
Pathogenic mycobacteria encounter multiple environments during macrophage infection.
Temporally, the bacteria are engulfed into the phagosome, lyse the phagosomal membrane …

[HTML][HTML] Computational identification of the proteins associated with quorum sensing and biofilm formation in Mycobacterium tuberculosis

SR Hegde - Frontiers in Microbiology, 2020 - frontiersin.org
With prolonged therapy and increased instances of drug resistance, tuberculosis is viewed
as a serious infectious disease causing high mortality. Emerging concepts in Mycobacterium …