Vascular calcification (VC) has been well-established as an independent and strong
predictor of cardiovascular diseases (CVD) as well as major cardiac adverse events …

Over the last decades, the association between vascular calcification (VC) and all-
cause/cardiovascular mortality, especially in patients with high atherogenic status, such as …

Abstract Pyruvate dehydrogenase kinase 4 (PDK4) is an important mitochondrial matrix
enzyme in cellular energy regulation. Previous studies suggested that PDK4 is increased in …

Matrix Gla protein (MGP) is a vitamin K-dependent protein, which is synthesized in bone and
many other mesenchymal cells, which is also highly expressed by vascular smooth muscle …

Methods: This will be a single-center randomized, prospective and open-label interventional
clinical trial of end stage renal failure patients on hemodialysis. We aim to recruit 200 …

Osteocalcin (OCN) is a bone-derived protein that is detected within human calcified vascular
tissue. Calcification is particularly prevalent in chronic kidney disease (CKD) patients but the …

Vascular calcification, characterized by the active deposition of calcium phosphate in the
vascular walls, is commonly observed in aging, diabetes mellitus and chronic kidney …

Background Lower limb arterial calcification is a frequent, underestimated but serious
complication of diabetes. The DIACART study is a prospective cohort study designed to …

Nϵ-carboxymethyl-lysine (CML), an advanced glycation end product, is involved in vascular
calcification (VC) in diabetic atherosclerosis. This study aimed to investigate the effects of …

Background: Pseudoxanthoma elasticum (PXE; OMIM 264800) is an inherited multisystem
disorder associated with accumulation of mineralized and fragmented elastic fibers in the …