The complexity of some diseases—as well as the inherent toxicity of certain drugs—has led
to an increasing interest in the development and optimization of drug-delivery systems …

There are many challenges involved in ocular drug delivery. These are a result of the many
tissue barriers and defense mechanisms that are present with the eye; such as the cornea …

Chitosan (CS) is a hemi-synthetic cationic linear polysaccharide produced by the
deacetylation of chitin. CS is non-toxic, highly biocompatible, and biodegradable, and it has …

Chitosan, derived from chitin, is a biopolymer consisting of arbitrarily distributed β-(1-4)-
linked D-glucosamine and N-acetyl-D-glucosamine that exhibits outstanding properties …

Chitosan nanoparticles (NPs) are widely studied as vehicles for drug, protein, and gene
delivery. However, lack of sufficient stability, particularly under physiological conditions …

Purpose The topically administered drugs through conventional delivery systems have low
bioavailability. Henceforth, the present study was designed to prepare and optimize …

Tumors located in the oral mucosa are challenging to treat since surgery can lead to
aesthetic, speech, and salivation problems, radiotherapy alone is often ineffective, and …

Novel drug delivery systems have emerged to treat bacterial keratitis, an acute infection of
the cornea. In this study, besifloxacin HCl loaded insert formulations were designed and …

The ocular drug discovery field has evidenced significant advancement in the past decade.
The FDA approvals of Rhopressa, Vyzulta, and Roclatan for glaucoma, Brolucizumab for wet …

The aim of this work was to evaluate the effectiveness of neat chitosan (CS) and its
derivatives with 2-acrylamido-2-methyl-1-propanesulfonic acid (AAMPS) and [2 …