PURPOSE To provide expert guidance to clinicians and policymakers in resource-
constrained settings on the management of patients with late-stage colorectal cancer …

Most cancer chemotherapy regimens rely on the use of two or more chemotherapeutic
agents. However, achieving the best possible dosing of the individual drugs can be …

The immune system plays a fundamental role at mucosal barriers in maintaining tissue
homeostasis. This is particularly true for the gut where cells are flooded with microbial …

Colorectal cancer stem cells have been proposed to drive disease progression, tumour
recurrence and chemoresistance. However, studies ablating leucine rich repeat containing …

In colon cancer, primary surgery followed by postoperative chemotherapy represents the
standard of care. In rectal cancer, the standard of care is preoperative radiotherapy or …

HJURP is a key factor for CENP-A deposition and maintenance in centromeres. The role of
mis-regulation of histone chaperones in cancer initiation and progression has been studied …

It has been reported that lncRNA NBR2 regulates cancer metabolism. We investigated the
role of NBR2 in colorectal cancer. We found that NBR2 was downregulated in colorectal …

Background As survival with metastatic colorectal cancer (CRC) and imaging modalities
improve, detection of ovarian metastases may be increasing. The ovary may serve as a …

Objective This study assessed predictors of survival after repeat hepatectomy and the
feasibility of a repeat hepatectomy after a major hepatectomy in the patients with colorectal …

Background In recent years, systemic chemotherapy has significantly improved the
prognosis of metastatic colorectal cancer (CRC); however, different patients have different …