Schizophrenia is a psychiatric disorder whose pathophysiology is largely unknown. It has a
heritability of 60-80%, much of which is attributable to common risk alleles, suggesting …

Pancreatic β cell failure is key to type 2 diabetes (T2D) onset and progression. Here, we
assess whether human β cell dysfunction induced by metabolic stress is reversible, evaluate …

Abstract We introduce Proteome-Wide Association Study (PWAS), a new method for
detecting gene-phenotype associations mediated by protein function alterations. PWAS …

Polycystic ovary syndrome (PCOS) is a highly heritable disorder, but only a small proportion
of the heritability can be accounted for by common genetic risk variants identified to date. It is …

The identification of individuals with a high risk of developing type 2 diabetes (T2D) is
fundamental for prevention. Here, we used a translational approach and prediction criteria to …

Deriving mechanisms of immune‐mediated disease from GWAS data remains a formidable
challenge, with attempts to identify causal variants being frequently hampered by strong …

Genome Wide Association Studies (GWAS) have successfully identified thousands of loci
associated with human diseases. Bayesian genetic fine-mapping studies aim to identify the …

Background Clinical trial data indicate that more intensive blood pressure (BP) lowering
below standard cut-off targets is associated with lower risks of strokes in the elderly. There is …

Admixed populations are routinely excluded from medical genomic studies due to concerns
over population structure. Here, we present a statistical framework and software package …

Over the last two decades, Genome-Wide Association Study (GWAS) has become a
canonical tool for exploratory genetic research, generating countless gene-phenotype …