The role of the cytokines and receptors of the IL-1 family in inflammation is well known.
Several cytokines of the family have a powerful inflammatory activity, with IL-1β being the …

The role of inflammation in atherosclerosis has been recognized several decades ago and
existing treatments provide benefits in part through non-specific anti-inflammatory actions …

Enhancing immune cell functions in tumors remains a major challenge in cancer
immunotherapy. Hypoxia is a common feature of solid tumors, and cells adapt by …

Hidradenitis suppurativa (HS) is a highly prevalent, morbid inflammatory skin disease with
limited treatment options. The major cell types and inflammatory pathways in skin of patients …

The complex tumor microenvironment is a most important factor in cancer development. The
biological microenvironment is composed of a variety of barriers including the extracellular …

Cell-surface protein-protein interactions (PPIs) mediate cell-cell communication, recognition,
and responses. We executed an interactome screen of 564 human cell-surface and secreted …

Toll-like receptors (TLR) that belong to the group of protein recognition receptor (PPR)
provide an innate immune response following the sensing of conserved pathogen …

Interleukin-33 (IL-33) is an epithelial-derived cytokine that can be released upon tissue
damage, stress, or infection, acting as an alarmin for the immune system. IL-33 has long …

Cytokines can trigger multiple signalling pathways, including Janus tyrosine kinases [JAK]
and signal transducers and activators of transcription [STATS] pathways. JAKs are …

Osteoarthritis (OA) is considered the most frequent degenerative disease and is
characterized by cartilage degradation and synovial inflammation. Fibroblast-like …