Dr. NO and Mr. Toxic–the versatile role of nitric oxide

C Porrini, N Ramarao, SL Tran - Biological Chemistry, 2020 - degruyter.com
Nitric oxide (NO) is present in various organisms from humans, to plants, fungus and
bacteria. NO is a fundamental signaling molecule implicated in major cellular functions. The …

Host-directed therapy as a novel treatment strategy to overcome tuberculosis: targeting immune modulation

S Ahmed, R Raqib, GH Guðmundsson, P Bergman… - Antibiotics, 2020 - mdpi.com
Tuberculosis (TB) is one of the leading causes of mortality and morbidity, particularly in
developing countries, presenting a major threat to the public health. The currently …

Comprehensive Examination of the Mouse Lung Metabolome Following Mycobacterium tuberculosis Infection Using a Multiplatform Mass Spectrometry Approach

M Fernández-García, F Rey-Stolle… - Journal of proteome …, 2020 - ACS Publications
The mechanisms whereby Mycobacterium tuberculosis (Mtb) rewires the host metabolism in
vivo are surprisingly unexplored. Here, we used three high-resolution mass spectrometry …

The echo of pulmonary tuberculosis: mechanisms of clinical symptoms and other disease-induced systemic complications

L Luies, I Du Preez - Clinical microbiology reviews, 2020 - Am Soc Microbiol
Clinical symptoms of active tuberculosis (TB) can range from a simple cough to more severe
reactions, such as irreversible lung damage and, eventually, death, depending on disease …

The association of tuberculosis mono-infection and tuberculosis-human immunodeficiency virus (TB-HIV) co-infection in the pathogenesis of hypertensive disorders of …

WN Phoswa, S Eche, OP Khaliq - Current Hypertension Reports, 2020 - Springer
Abstract Purpose of Review This review highlights the impact of TB mono-infection and TB-
HIV co-infection on the pathogenesis of adverse maternal outcomes such as hypertensive …

Antibacterial activity of high-dose nitric oxide against pulmonary Mycobacterium abscessus disease

K Bogdanovski, T Chau, CJ Robinson… - Access …, 2020 - microbiologyresearch.org
Introduction. Mycobacterium abscessus is an emerging pulmonary pathogen with limited
treatment options. Nitric oxide (NO) demonstrates antibacterial activity against various …

Mycobacterium smegmatis Bacteria Expressing Mycobacterium tuberculosis-Specific Rv1954A Induce Macrophage Activation and Modulate the Immune Response

SK Arora, N Naqvi, A Alam, J Ahmad… - Frontiers in Cellular …, 2020 - frontiersin.org
Mycobacterium tuberculosis (M. tb), the intracellular pathogen causing tuberculosis, has
developed mechanisms that endow infectivity and allow it to modulate host immune …

Immunodominant Mycobacterium tuberculosis Protein Rv1507A Elicits Th1 Response and Modulates Host Macrophage Effector Functions

SK Arora, A Alam, N Naqvi, J Ahmad… - Frontiers in …, 2020 - frontiersin.org
Mycobacterium tuberculosis (M. tb) persists as latent infection in nearly a quarter of the
global population and remains the leading cause of death among infectious diseases. While …

Nitric oxide balance in health and diseases: Implications for new treatment strategies

MA Akanji, AA Adeyanju, D Rotimi… - The Open …, 2020 - benthamopen.com
Nitric Oxide (NO) is an essential signaling molecule with diverse physiological functions in
humans. The steady-state concentration and site of production of nitric oxide determine its …

Plasma levels of tumor necrosis factor-alpha, interferon-gamma, inducible nitric oxide synthase, and 3-nitrotyrosine in drug-resistant and drug-sensitive pulmonary …

EB Bolajoko, OG Arinola, GN Odaibo… - … International Journal of …, 2020 - journals.lww.com
Background: Nigeria is one of the countries with a high burden of tuberculosis (TB) in the
world. TB associated inflammation is reported to be central to progression from latent TB to …