Daily dietary potassium (K+) intake may be as large as the extracellular K+ pool. To avoid
acute hyperkalemia, rapid removal of K+ from the extracellular space is essential. This is …

Coronavirus disease 2019 (COVID-19) is commonly associated with kidney damage, and
the angiotensin converting enzyme 2 (ACE2) receptor for SARS-CoV-2 is highly expressed …

Biology has taught us that a protein as abundantly made and conserved among species as
Tamm–Horsfall protein (THP or uromodulin) cannot just be a waste product serving no …

Ageing is characterized by a progressive loss of physiological integrity, leading to impaired
function and increased vulnerability to death. Despite rapid advances over recent years …

Background Current management of AKI, a potentially fatal disorder that can also initiate or
exacerbate CKD, is merely supportive. Therefore, deeper understanding of the molecular …

Uric acid, the end product of purine metabolism, plays a key role in the pathogenesis of gout
and other disease processes. The circulating serum uric acid concentration is governed by …

Chronic hyperglycemia is known to disrupt the proteolytic milieu, initiating compensatory
and maladaptive pathways in the diabetic kidney. Such changes in intrarenal proteolysis are …

Cranberry is a well-known functional food, but the compounds directly responsible for many
of its reported health benefits remain unidentified. Complex carbohydrates, specifically …

The thick ascending limb of the loop of Henle (TAL) is the first segment of the distal nephron,
extending through the whole outer medulla and cortex, two regions with different …

The genetic disease Gitelman syndrome, knockout mice, and pharmacological blockade
with thiazide diuretics have revealed that reduced activity of the NaCl cotransporter (NCC) …