Reactive oxygen species (ROS) are byproducts of aerobic respiration and signaling
molecules that control various cellular functions. Nrf2 governs the gene expression of …

Lysosomes figure prominently in theories of aging as the proteolytic system most
responsible for eliminating growing burdens of damaged proteins and organelles in aging …

Chromatin instability and mitochondrial decline are conserved processes that contribute to
cellular aging. Although both processes have been explored individually in the context of …

Aging is an elusive property of life, and many important questions about aging depend on its
definition. This article proposes to draw a definition from the scientific literature on aging …

Sirtuin 6 (SIRT6) is a nuclear NAD+-dependent deacetylase of histone H3 that regulates
genome stability and gene expression. However, nonhistone substrates and additional …

Caloric restriction (CR) is a traditional but scientifically verified approach to promoting health
and increasing lifespan. CR exerts its effects through multiple molecular pathways that …

Extrachromosomal circular DNA (eccDNA) elements of chromosomal origin are known to be
common in a number of eukaryotic species. However, it remains to be addressed whether …

Still unresolved is the question of how a lifetime accumulation of somatic gene copy number
alterations impact organ functionality and aging and age-related pathologies. Such an issue …

The protein acetylation of either the α-amino groups of amino-terminal residues or of internal
lysine or cysteine residues is one of the major posttranslational protein modifications that …

Oxidative stress is one of the main causes of aging. The process of physiological aging is
always accompanied by increased levels of endogenous oxidative stress. Exogenous …