EZH2: a novel target for cancer treatment
R Duan, W Du, W Guo - Journal of hematology & oncology, 2020 - Springer
Enhancer of zeste homolog 2 (EZH2) is enzymatic catalytic subunit of polycomb repressive
complex 2 (PRC2) that can alter downstream target genes expression by trimethylation of …
complex 2 (PRC2) that can alter downstream target genes expression by trimethylation of …
Role of JAK/STAT3 signaling in the regulation of metastasis, the transition of cancer stem cells, and chemoresistance of cancer by epithelial–mesenchymal transition
W Jin - Cells, 2020 - mdpi.com
The JAK/STAT3 signaling pathway plays an essential role in various types of cancers.
Activation of this pathway leads to increased tumorigenic and metastatic ability, the transition …
Activation of this pathway leads to increased tumorigenic and metastatic ability, the transition …
EZH2-targeted therapies in cancer: hype or a reality
ML Eich, M Athar, JE Ferguson III, S Varambally - Cancer research, 2020 - AACR
Next-generation genomic sequencing has identified multiple novel molecular alterations in
cancer. Since the identification of DNA methylation and histone modification, it has become …
cancer. Since the identification of DNA methylation and histone modification, it has become …
The promise for histone methyltransferase inhibitors for epigenetic therapy in clinical oncology: a narrative review
Epigenetic processes are essential for normal development and the maintenance of tissue-
specific gene expression in mammals. Changes in gene expression and malignant cellular …
specific gene expression in mammals. Changes in gene expression and malignant cellular …
No easy way out for EZH2: its pleiotropic, noncanonical effects on gene regulation and cellular function
Enhancer of zeste homolog 2 (EZH2) plays critical roles in a range of biological processes
including organ development and homeostasis, epigenomic and transcriptomic regulation …
including organ development and homeostasis, epigenomic and transcriptomic regulation …
Critical role of matrix metalloproteinase 14 in adipose tissue remodeling during obesity
Fibrosis is recognized as the major pathological change in adipose tissue during the
development of obesity. However, the detailed mechanisms governing the interactions …
development of obesity. However, the detailed mechanisms governing the interactions …
An important role for DNMT3A-mediated DNA methylation in cardiomyocyte metabolism and contractility
A Madsen, G Höppner, J Krause, MN Hirt, SD Laufer… - Circulation, 2020 - Am Heart Assoc
Background: DNA methylation acts as a mechanism of gene transcription regulation. It has
recently gained attention as a possible therapeutic target in cardiac hypertrophy and heart …
recently gained attention as a possible therapeutic target in cardiac hypertrophy and heart …
Post-translational modifications of PRC2: signals directing its activity
Abstract Polycomb repressive complex 2 (PRC2) is a chromatin-modifying enzyme that
catalyses the methylation of histone H3 at lysine 27 (H3K27me1/2/3). This complex …
catalyses the methylation of histone H3 at lysine 27 (H3K27me1/2/3). This complex …
Small molecule approaches for targeting the polycomb repressive complex 2 (PRC2) in cancer
The polycomb repressive complex 2 (PRC2) is composed of three core subunits, enhancer
of zeste 2 (EZH2), embryonic ectoderm development (EED), and suppressor of zeste 12 …
of zeste 2 (EZH2), embryonic ectoderm development (EED), and suppressor of zeste 12 …
lncRNA PVT1 promotes hepatitis B virus‑positive liver cancer progression by disturbing histone methylation on the c‑Myc promoter
B Jiang, B Yang, Q Wang, X Zheng… - Oncology …, 2020 - spandidos-publications.com
Abstract Long noncoding RNA (LncRNA) PVT1 has recently been reported to be involved in
the development of hepatocellular carcinoma (HCC). We aimed to elucidate the correlation …
the development of hepatocellular carcinoma (HCC). We aimed to elucidate the correlation …