The COVID-19 pandemic has infected millions of people with no clear signs of abatement
owing to the high prevalence, long incubation period and lack of established treatments or …

Consensus among experts is that only an effective COVID-19 vaccine will end the
pandemic. This Comment focuses on how this pandemic has accelerated the development …

Background Testing of vaccine candidates to prevent infection with severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) in an older population is important, since increased …

Aging is associated with increased morbidity arising from a range of tissue dysfunctions. A
common denominator of age-associated frailty is increased baseline inflammation, called …

Age-associated changes in immune cells have been linked to an increased risk for infection.
However, a global and detailed characterization of the changes that human circulating …

The ongoing worldwide increase in life expectancy portends a rising prevalence of age-
related cardiovascular (CV) diseases in the coming decades that demands a deeper …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is characterized
by a high mortality of elderly men with age-related comorbidities. In most of these patients …

The ongoing pandemic severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)
causes a disproportionate number of severe cases and deaths in older adults. Severe SARS …

Older adults are at greatest risk of severe disease and death due to coronavirus disease
2019 (COVID-19). Globally, persons older than 65 years comprise 9% of the population, 1 …

Alterations in the immune system with aging are considered to underlie many age-related
diseases. However, many elderly individuals remain healthy until even a very advanced …