New insights into drug discovery targeting tau protein
Y Soeda, A Takashima - Frontiers in molecular neuroscience, 2020 - frontiersin.org
Microtubule-associated protein tau is characterized by the fact that it is an intrinsically
disordered protein due to its lack of a stable conformation and high flexibility. Intracellular …
disordered protein due to its lack of a stable conformation and high flexibility. Intracellular …
Chemokines in chronic pain: cellular and molecular mechanisms and therapeutic potential
Chronic pain resulting from nerve injury, tissue inflammation, and tumor invasion or
treatment, is a major health problem impacting the quality of life and producing a significant …
treatment, is a major health problem impacting the quality of life and producing a significant …
SARS‐CoV‐2 targets neurons of 3D human brain organoids
A Ramani, L Müller, PN Ostermann, E Gabriel… - The EMBO …, 2020 - embopress.org
COVID‐19 pandemic caused by SARS‐CoV‐2 infection is a public health emergency.
COVID‐19 typically exhibits respiratory illness. Unexpectedly, emerging clinical reports …
COVID‐19 typically exhibits respiratory illness. Unexpectedly, emerging clinical reports …
Diffuse axonal injury predicts neurodegeneration after moderate–severe traumatic brain injury
Traumatic brain injury is associated with elevated rates of neurodegenerative diseases such
as Alzheimer's disease and chronic traumatic encephalopathy. In experimental models …
as Alzheimer's disease and chronic traumatic encephalopathy. In experimental models …
[HTML][HTML] Advances and considerations in AD tau-targeted immunotherapy
The multifactorial and complex nature of Alzheimer's disease (AD) has made it difficult to
identify therapeutic targets that are causally involved in the disease process. However …
identify therapeutic targets that are causally involved in the disease process. However …
Tau immunotherapies: Lessons learned, current status and future considerations
LA Sandusky-Beltran, EM Sigurdsson - Neuropharmacology, 2020 - Elsevier
The majority of clinical trials targeting the tau protein in Alzheimer's disease and other
tauopathies are tau immunotherapies. Because tau pathology correlates better with the …
tauopathies are tau immunotherapies. Because tau pathology correlates better with the …
Extracellular vesicles derived from human ES-MSCs protect retinal ganglion cells and preserve retinal function in a rodent model of optic nerve injury
SZ Seyedrazizadeh, S Poosti, A Nazari… - Stem cell research & …, 2020 - Springer
Background Retinal and/or optic nerve injury is one of the leading causes of blindness due
to retinal ganglion cell (RGC) degeneration. There have been extensive efforts to suppress …
to retinal ganglion cell (RGC) degeneration. There have been extensive efforts to suppress …
Traumatic brain injury triggers APP and Tau cleavage by delta-secretase, mediating Alzheimer's disease pathology
Traumatic brain injury (TBI) is associated in some studies with clinical dementia, and
neuropathological features, including amyloid plaque deposition and Tau neurofibrillary …
neuropathological features, including amyloid plaque deposition and Tau neurofibrillary …
Tau filament self-assembly and structure: tau as a therapeutic target
Tau plays an important pathological role in a group of neurodegenerative diseases called
tauopathies, including Alzheimer's disease, Pick's disease, chronic traumatic …
tauopathies, including Alzheimer's disease, Pick's disease, chronic traumatic …
Peptidyl-Prolyl Cis/Trans Isomerase Pin1 and Alzheimer's Disease
L Wang, Y Zhou, D Chen, TH Lee - Frontiers in cell and …, 2020 - frontiersin.org
Alzheimer's disease (AD) is the most common cause of dementia with cognitive decline. The
neuropathology of AD is characterized by intracellular aggregation of neurofibrillary tangles …
neuropathology of AD is characterized by intracellular aggregation of neurofibrillary tangles …