Animal models in neuropsychiatric research need validation. One way to address external
validity is systematic reviews and meta-analyses. The present study presents a meta …

Monoaminergic and oxidative dysfunctions have been reported to play a role in depression.
The present study investigated the antioxidant potential as well as the antidepressant-like …

Abstract Aim Astroglial connexins (Cxs) 30 and 43 are engaged in gap junction and
hemichannel activities. Evidence suggests that these functional entities contribute to …

Rationale Major depressive disorder is a psychiatric disorder that requires considerable
attention, since it dramatically impairs the quality of life of the sufferers. The available …

The processes of memory formation and its storage are extremely dynamic. Therefore, the
determination of the nature and temporal evolution of the changes that underlie the …

Leptadenia arborea (Asclepiadaceae) is a plant used in traditional medicine to treat syphilis,
migraine, and mental illnesses. The aim of our study was to investigate possible …

hydroxytryptamine (5-HT, serotonin) is a major neurotransmitter involved in the modulation
of behavior and the manifestation of various psychiatric disorders, and is a pharmacological …

Piperazine derivatives are an attractive class of chemical compounds for the treatment of
various mental illness. Herein, we demonstrated the synthesis of LQFM212, a piperazine …

Depression is emerging as a major global issue. There are several antidepressants
available in the market, but their efficacy is usually unpredictable. Therefore, there is a need …

Adolescent exposure to caffeine has been shown to decrease immobility in the forced swim
test, suggesting and antidepressant-like effect of caffeine; however, studies have produced …