COVID-19: Melatonin as a potential adjuvant treatment

R Zhang, X Wang, L Ni, X Di, B Ma, S Niu, C Liu… - Life sciences, 2020 - Elsevier
This article summarizes the likely benefits of melatonin in the attenuation of COVID-19
based on its putative pathogenesis. The recent outbreak of COVID-19 has become a …

[HTML][HTML] Melatonin for the treatment of sepsis: the scientific rationale

RMLC Biancatelli, M Berrill… - Journal of thoracic …, 2020 - ncbi.nlm.nih.gov
Sepsis affects 30 million people worldwide, leading to 6 million deaths every year (WHO),
and despite decades of research, novel initiatives are drastically needed. According to the …

Melatonin as adjuvant treatment for coronavirus disease 2019 pneumonia patients requiring hospitalization (MAC-19 PRO): a case series

RR Castillo, GRA Quizon, MJM Juco… - Melatonin …, 2020 - melatonin-research.net
Abstract Treatment for coronavirus disease 2019 (COVID19) pneumonia remains empirical
and the search for therapies that can improve outcomes continues. Melatonin has been …

The role of melatonin and melatonin receptor agonist in the prevention of sleep disturbances and delirium in intensive care unit–a clinical review

K Lewandowska, MA Małkiewicz, M Siemiński… - Sleep medicine, 2020 - Elsevier
Aim The intensive care unit (ICU) environment contributes to the development of sleep
disturbances. Sleep disturbances, sleep fragmentation, and multiple awakening episodes …

The effect of melatonin on delirium in hospitalised patients: A systematic review and meta-analyses with trial sequential analysis

KT Ng, WY Teoh, AJ Khor - Journal of clinical anesthesia, 2020 - Elsevier
Abstracts Objectives Melatonin is an endogenous hormone, which regulates circadian
rhythms and promotes sleep. In recent years, several randomised controlled trials examining …

Effect of exogenous melatonin administration in critically ill patients on delirium and sleep: a randomized controlled trial

J Bellapart, V Appadurai… - … Care Research and …, 2020 - Wiley Online Library
Introduction. Sleep deprivation is a contributor for delirium in intensive care. Melatonin has
been proposed as a pharmacological strategy to improve sleep, but studies have shown that …

[PDF][PDF] A narrative literature review of global pandemic novel coronavirus disease 2019 (COVID-19): epidemiology, virology, potential drug treatments available

VB Hange - Arch. Med, 2020 - researchgate.net
Coronaviruses (CoVs) are the largest group of viruses belonging to the Nidovirales order,
which includes Coronaviridae, Arteriviridae, Mesoniviridae and Roniviridae families …

Oral substitution of melatonin in critical care: a pharmacokinetic study in patients with intracranial hemorrhage

M Rouini, NK Rad, A Najafi… - Journal of …, 2020 - publish.kne-publishing.com
Background: Intracranial hemorrhage (ICH) is a devastating condition with a high mortality
and morbidity rate. Neuroprotective agents protect surrounding brain tissue from the toxic …

Effects of Melatonin and Flavonoid-Rich Fractions of Chromolaena odorata on the Alteration of Proinflammatory Cytokines and Nitric Oxide Induced by Aflatoxin B1 in …

AS Amid, OA Makinde… - Journal of Interferon & …, 2020 - liebertpub.com
In this study, we investigated serum interleukin-1 beta (IL-1β) and tumor necrosis factor
alpha (TNF-α) after ingestion of aflatoxin B1 (AFB1) in rats. We also studied the effects of …

Factors predicting prognosis of oncology patients followed in the intensive care unit

A Oğul, S Paydaş, E Karakoç, G Seydaoğlu… - Cukurova Medical …, 2020 - dergipark.org.tr
Purpose: The aim of the study is to determine the factors affecting the mortality of oncology
patients followed in the intensive care unit (ICU). Materials and Methods: In this study 100 …