Diabetes is one of the fastest growing diseases worldwide, projected to affect 693 million
adults by 2045. Devastating macrovascular complications (cardiovascular disease) and …

Cognitive impairment is an increasingly recognized major cause of chronic disability and is
commonly found in patients with chronic kidney disease (CKD). Knowledge of the …

Fine-mapping aims to identify causal variants impacting complex traits. We propose
PolyFun, a computationally scalable framework to improve fine-mapping accuracy by …

Mendelian randomisation (MR) analysis is an important tool to elucidate the causal
relevance of environmental and biological risk factors for disease. However, causal …

Membranous Nephropathy (MN) is a rare autoimmune cause of kidney failure. Here we
report a genome-wide association study (GWAS) for primary MN in 3,782 cases and 9,038 …

Assessment of GFR is central to clinical practice, research, and public health. Current
Kidney Disease Improving Global Outcomes guidelines recommend measurement of serum …

Chronic kidney diseases (CKDs) are currently classified according to their clinical features,
associated comorbidities and pattern of injury on biopsy. Even within a given classification …

Background: High blood pressure (BP) is a risk factor for cardiovascular morbidity and
mortality. While BP is regulated by the function of kidney, vasculature, and sympathetic …

Lupus nephritis (LN) is a common manifestation of systemic lupus erythematosus that can
lead to irreversible renal impairment. Although the prognosis of LN has improved …

Background Studies have found sleeping behaviors, such as sleep duration, to be
associated with kidney function and cardiovascular disease risk. However, whether short or …