Is there enough evidence to classify cycloalkyl amine substituents as structural alerts?
AS Kalgutkar, JP Driscoll - Biochemical Pharmacology, 2020 - Elsevier
Basic amine substituents provide several pharmacokinetic benefits relative to acidic and
neutral functional groups, and have been extensively utilized as substituents of choice in …
neutral functional groups, and have been extensively utilized as substituents of choice in …
In vitro biotransformation of pyrrolizidine alkaloids in different species: part II—identification and quantitative assessment of the metabolite profile of six structurally …
I Geburek, D Schrenk, A These - Archives of toxicology, 2020 - Springer
Pyrrolizidine alkaloids (PA) exert their toxic effects only after bioactivation. Although their
toxicity has already been studied and metabolic pathways including important metabolites …
toxicity has already been studied and metabolic pathways including important metabolites …
Metabolic forest: predicting the diverse structures of drug metabolites
Adverse drug metabolism often severely impacts patient morbidity and mortality.
Unfortunately, drug metabolism experimental assays are costly, inefficient, and slow …
Unfortunately, drug metabolism experimental assays are costly, inefficient, and slow …
The Vouros Odyssey. Liquid chromatography/mass spectrometry from a chromatographic perspective and a Theseus Paradox.
T Covey - Mass Spectrometry Reviews, 2020 - search.ebscohost.com
The Vouros Odyssey. Liquid chromatography/mass spectrometry from a chromatographic
perspective and a Theseus Paradox Page 1 Received: 22 January 2018 | Accepted: 7 …
perspective and a Theseus Paradox Page 1 Received: 22 January 2018 | Accepted: 7 …