Systematic multi-omics integration (MOI) approach in plant systems biology

IN Jamil, J Remali, KA Azizan… - Frontiers in plant …, 2020 - frontiersin.org
Across all facets of biology, the rapid progress in high-throughput data generation has
enabled us to perform multi-omics systems biology research. Transcriptomics, proteomics …

[PDF][PDF] Methods and algorithms for correlation analysis in R

D Makowski, MS Ben-Shachar, I Patil… - Journal of Open Source …, 2020 - joss.theoj.org
Correlations tests are arguably one of the most commonly used statistical procedures, and
are used as a basis in many applications such as exploratory data analysis, structural …

Long-term nutrient inputs shift soil microbial functional profiles of phosphorus cycling in diverse agroecosystems

Z Dai, G Liu, H Chen, C Chen, J Wang, S Ai… - The ISME …, 2020 - academic.oup.com
Microorganisms play an important role in soil phosphorus (P) cycling and regulation of P
availability in agroecosystems. However, the responses of the functional and ecological …

[HTML][HTML] Abundance of kinless hubs within soil microbial networks are associated with high functional potential in agricultural ecosystems

Y Shi, M Delgado-Baquerizo, Y Li, Y Yang… - Environment …, 2020 - Elsevier
Microbial taxa within complex ecological networks can be classified by their universal roles
based on their level of connectivity with other taxa. Highly connected taxa within an …

Integrated proteomics reveals brain-based cerebrospinal fluid biomarkers in asymptomatic and symptomatic Alzheimer's disease

L Higginbotham, L Ping, EB Dammer, DM Duong… - Science …, 2020 - science.org
Alzheimer's disease (AD) lacks protein biomarkers reflective of its diverse underlying
pathophysiology, hindering diagnostic and therapeutic advancements. Here, we used …

Decoding the development of the human hippocampus

S Zhong, W Ding, L Sun, Y Lu, H Dong, X Fan, Z Liu… - Nature, 2020 - nature.com
The hippocampus is an important part of the limbic system in the human brain that has
essential roles in spatial navigation and the consolidation of information from short-term …

Behavioral state coding by molecularly defined paraventricular hypothalamic cell type ensembles

S Xu, H Yang, V Menon, AL Lemire, L Wang, FE Henry… - Science, 2020 - science.org
INTRODUCTION Brain function is often compared to an orchestral ensemble, where
subgroups of neurons that have similar activity are analogous to different types of …

Mitochondrial peptide BRAWNIN is essential for vertebrate respiratory complex III assembly

S Zhang, B Reljić, C Liang, B Kerouanton… - Nature …, 2020 - nature.com
The emergence of small open reading frame (sORF)-encoded peptides (SEPs) is rapidly
expanding the known proteome at the lower end of the size distribution. Here, we show that …

Longitudinal transcriptome analyses show robust T cell immunity during recovery from COVID-19

HY Zheng, M Xu, CX Yang, RR Tian, M Zhang… - Signal transduction and …, 2020 - nature.com
Understanding the processes of immune regulation in patients infected with the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial for improving treatment …

Crop production correlates with soil multitrophic communities at the large spatial scale

K Fan, M Delgado-Baquerizo, Y Zhu, H Chu - Soil Biology and …, 2020 - Elsevier
Strong associations exist between microbial communities and soil functions in natural
ecosystems at large spatial scales; however, it is unclear whether these linkages are …