Age-related impairment of macroautophagy/autophagy and loss of cardiac tissue
homeostasis contribute significantly to cardiovascular diseases later in life. MTOR …

Progress in the identification of causal genes and understanding of the mechanism
underlying kidney disease is hindered by the almost exclusive use of a few animal models …

The class of human genetic kidney diseases is extremely broad and heterogeneous.
Accordingly, the range of associated disease phenotypes is highly variable. Many children …

Background Understanding podocyte-specific responses to injury at a systems level is
difficult because injury leads to podocyte loss or an increase of extracellular matrix, altering …

Drosophila nephrocytes share functional, structural and molecular similarities with human
podocytes. It is known that podocytes express the rabphilin 3A (RPH3A)-RAB3A complex …

OBJECTIVE: Kidney stone formers have a high rate of stone recurrence after kidney stone
removal surgery and there is no effective medication for treatment. Hydroxycitric acid (HCA) …

Background Studies have linked mutations in genes encoding the eight-protein exocyst
protein complex to kidney disease, but the underlying mechanism is unclear. Because …

Aldosterone is produced by the mammalian adrenal cortex to modulate blood pressure and
fluid balance; however, excessive, prolonged aldosterone promotes fibrosis and kidney …

Obesity-related renal lipotoxicity and chronic kidney disease (CKD) are prevalent
pathologies with complex aetiologies. One hallmark of renal lipotoxicity is the ectopic …