Cervicovaginal microbiome and natural history of HPV in a longitudinal study

M Usyk, CP Zolnik, PE Castle, C Porras… - PLoS …, 2020 - journals.plos.org
Background Human papillomavirus (HPV) infection is one of the most common sexually
transmitted infections. However, only a small percentage of high-risk (HR) HPV infections …

The genetic architecture of high bone mass

CL Gregson, EL Duncan - Frontiers in Endocrinology, 2020 - frontiersin.org
The phenotypic trait of high bone mass (HBM) is an excellent example of the nexus between
common and rare disease genetics. HBM may arise from carriage of many 'high bone …

Vaccinomics and adversomics in the era of precision medicine: a review based on HBV, MMR, HPV, and COVID-19 vaccines

J Omersel, N Karas Kuželički - Journal of clinical medicine, 2020 - mdpi.com
Precision medicine approaches based on pharmacogenomics are now being successfully
implemented to enable physicians to predict more efficient treatments and prevention …

Cancer PRSweb: an online repository with polygenic risk scores for major cancer traits and their evaluation in two independent biobanks

LG Fritsche, S Patil, LJ Beesley, P VandeHaar… - The American Journal of …, 2020 - cell.com
To facilitate scientific collaboration on polygenic risk scores (PRSs) research, we created an
extensive PRS online repository for 35 common cancer traits integrating freely available …

[HTML][HTML] Genomewide association study of acute anterior uveitis identifies new susceptibility loci

XF Huang, Z Li, E De Guzman, P Robinson… - … & Visual Science, 2020 - arvojournals.org
Purpose: Acute anterior uveitis (AAU) is a common intraocular inflammatory disease. AAU
occurs in 30% to 50% of patients with ankylosing spondylitis (AS), and both conditions are …

HLA class I antigen processing machinery defects in cancer cells—Frequency, functional significance, and clinical relevance with special emphasis on their role in T …

B Seliger, S Ferrone - Biomarkers for Immunotherapy of Cancer: Methods …, 2020 - Springer
MHC class I antigen abnormalities have been shown to be one of the major immune escape
mechanisms murine and human cancer cells utilize to avoid recognition and destruction by …

HLA-DRB1 alleles and cervical cancer: A meta-analysis of 36 case-control studies

AB Kamiza, S Kamiza, CG Mathew - Cancer epidemiology, 2020 - Elsevier
Background Human leukocyte antigens (HLA) are encoded by closely linked genetic loci,
and are important in cervical carcinogenesis. The association between HLA-DRB1 alleles …

Host-defense peptides caerin 1.1 and 1.9 stimulate TNF-alpha-dependent apoptotic signals in human cervical cancer HeLa cells

G Ni, S Chen, M Chen, J Wu, B Yang, J Yuan… - Frontiers in cell and …, 2020 - frontiersin.org
Host defense caerin 1.1 and 1.9 peptides, isolated from the glandular secretion of Australian
tree frogs, the genus Litoria, have been previously shown to have multiple biological …

Association of genomic variants at the human leukocyte antigen locus with cervical cancer risk, HPV status and gene expression levels

D Ramachandran, P Schürmann, Q Mao… - … Journal of Cancer, 2020 - Wiley Online Library
The human leukocyte antigen (HLA) locus on chromosome 6 has been reported to be
associated with cervical cancer. We investigated two independent single‐nucleotide …

Fine mapping of the major histocompatibility complex region and association of the HLA-B* 52: 01 allele with cervical cancer in Japanese women

T Masuda, H Ito, J Hirata, S Sakaue, Y Ueda… - JAMA Network …, 2020 - jamanetwork.com
Importance Understanding the genetic contribution of the major histocompatibility complex
(MHC) region to the risk of cervical cancer (CC) will help understand how immune …