Mapping genomic loci prioritises genes and implicates synaptic biology in schizophrenia
Schizophrenia Working Group of the Psychiatric … - MedRxiv, 2020 - medrxiv.org
Schizophrenia is a psychiatric disorder whose pathophysiology is largely unknown. It has a
heritability of 60-80%, much of which is attributable to common risk alleles, suggesting …
heritability of 60-80%, much of which is attributable to common risk alleles, suggesting …
Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits
Problematic alcohol use (PAU) is a leading cause of death and disability worldwide.
Although genome-wide association studies have identified PAU risk genes, the genetic …
Although genome-wide association studies have identified PAU risk genes, the genetic …
A large-scale genome-wide association study meta-analysis of cannabis use disorder
Background Variation in liability to cannabis use disorder has a strong genetic component
(estimated twin and family heritability about 50–70%) and is associated with negative …
(estimated twin and family heritability about 50–70%) and is associated with negative …
Minimal phenotyping yields genome-wide association signals of low specificity for major depression
Minimal phenotyping refers to the reliance on the use of a small number of self-reported
items for disease case identification, increasingly used in genome-wide association studies …
items for disease case identification, increasingly used in genome-wide association studies …
Towards reproducible brain-wide association studies
Magnetic resonance imaging (MRI) continues to drive many important neuroscientific
advances. However, progress in uncovering reproducible associations between individual …
advances. However, progress in uncovering reproducible associations between individual …
Heterogeneity and polygenicity in psychiatric disorders: a genome-wide perspective
Genome-wide association studies (GWAS) have been performed for many psychiatric
disorders and revealed a complex polygenic architecture linking mental and physical health …
disorders and revealed a complex polygenic architecture linking mental and physical health …
Polygenic risk score contribution to psychosis prediction in a target population of persons at clinical high risk
DO Perkins, L Olde Loohuis, J Barbee… - American Journal of …, 2020 - Am Psychiatric Assoc
Objective: The 2-year risk of psychosis in persons who meet research criteria for a high-risk
syndrome is about 15%− 25%; improvements in risk prediction accuracy would benefit the …
syndrome is about 15%− 25%; improvements in risk prediction accuracy would benefit the …
Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium
R Polimanti, RK Walters, EC Johnson… - Molecular …, 2020 - nature.com
To provide insights into the biology of opioid dependence (OD) and opioid use (ie,
exposure, OE), we completed a genome-wide analysis comparing 4503 OD cases, 4173 …
exposure, OE), we completed a genome-wide analysis comparing 4503 OD cases, 4173 …
Genomic influences on self-reported childhood maltreatment
Childhood maltreatment is highly prevalent and serves as a risk factor for mental and
physical disorders. Self-reported childhood maltreatment appears heritable, but the specific …
physical disorders. Self-reported childhood maltreatment appears heritable, but the specific …
Genetic comorbidity between major depression and cardio‐metabolic traits, stratified by age at onset of major depression
It is imperative to understand the specific and shared etiologies of major depression and
cardio‐metabolic disease, as both traits are frequently comorbid and each represents a …
cardio‐metabolic disease, as both traits are frequently comorbid and each represents a …