Structure of nucleosome-bound human BAF complex
Mammalian SWI/SNF family chromatin remodelers, BRG1/BRM-associated factor (BAF) and
polybromo-associated BAF (PBAF), regulate chromatin structure and transcription, and their …
polybromo-associated BAF (PBAF), regulate chromatin structure and transcription, and their …
Cryo-EM structure of SWI/SNF complex bound to a nucleosome
The chromatin-remodelling complex SWI/SNF is highly conserved and has critical roles in
various cellular processes, including transcription and DNA-damage repair,. It hydrolyses …
various cellular processes, including transcription and DNA-damage repair,. It hydrolyses …
Translational genomics of malignant rhabdoid tumours: Current impact and future possibilities
MA Finetti, Y Grabovska, S Bailey… - Seminars in Cancer …, 2020 - Elsevier
Abstract Malignant Rhabdoid Tumours (MRT) are the quintessential example of an
epigenetic cancer. Mutation of a single gene, SMARCB1 or more rarely SMARCA4, is …
epigenetic cancer. Mutation of a single gene, SMARCB1 or more rarely SMARCA4, is …
[HTML][HTML] Chromatin remodelling comes into focus
R Sundaramoorthy, T Owen-Hughes - F1000Research, 2020 - ncbi.nlm.nih.gov
ATP-dependent chromatin remodelling enzymes are molecular machines that act to
reconfigure the structure of nucleosomes. Until recently, little was known about the structure …
reconfigure the structure of nucleosomes. Until recently, little was known about the structure …
ARID4B is critical for mouse embryonic stem cell differentiation towards mesoderm and endoderm, linking epigenetics to pluripotency exit
Distinct cell types emerge from embryonic stem cells through a precise and coordinated
execution of gene expression programs during lineage commitment. This is established by …
execution of gene expression programs during lineage commitment. This is established by …
Structure of the yeast Swi/Snf complex in a nucleosome free state
SWI/SNF remodelers play a key role in regulating chromatin architecture and gene
expression. Here, we report the cryo-EM structure of the Saccharomyces cerevisiae Swi/Snf …
expression. Here, we report the cryo-EM structure of the Saccharomyces cerevisiae Swi/Snf …
Alternative splicing signatures in preimplantation embryo development
GG Tian, J Li, J Wu - Cell & Bioscience, 2020 - Springer
Background Preimplantation embryo development is a highly ordered sequence of
processes and it requires a precise temporal and spatial control of gene expression …
processes and it requires a precise temporal and spatial control of gene expression …
Taf14 is required for the stabilization of transcription pre-initiation complex in Saccharomyces cerevisiae
K Peil, H Jürgens, J Luige, K Kristjuhan… - Epigenetics & …, 2020 - Springer
Background The YEATS domain is a highly conserved protein structure that interacts with
acetylated and crotonylated lysine residues in N-terminal tails of histones. The budding …
acetylated and crotonylated lysine residues in N-terminal tails of histones. The budding …
Elucidating the regulatory mechanism of Swi1 prion in global transcription and stress responses
Transcriptional regulators are prevalent among identified prions in Saccharomyces
cerevisiae, however, it is unclear how prions affect genome-wide transcription. We show …
cerevisiae, however, it is unclear how prions affect genome-wide transcription. We show …
Snf5 and Swi3 subcomplex formation is required for SWI/SNF complex function in yeast
The SWI/SNF chromatin remodeling complex, which alters nucleosome positions by either
evicting histones or sliding nucleosomes on DNA, is highly conserved from yeast to humans …
evicting histones or sliding nucleosomes on DNA, is highly conserved from yeast to humans …