Next generation sequencing and bioinformatics analysis of family genetic inheritance
Mendelian and complex genetic trait diseases continue to burden and affect society both
socially and economically. The lack of effective tests has hampered diagnosis thus, the …
socially and economically. The lack of effective tests has hampered diagnosis thus, the …
Common diseases alter the physiological age-related blood microRNA profile
Aging is a key risk factor for chronic diseases of the elderly. MicroRNAs regulate post-
transcriptional gene silencing through base-pair binding on their target mRNAs. We …
transcriptional gene silencing through base-pair binding on their target mRNAs. We …
Metabolome and transcriptome analyses reveal chlorophyll and anthocyanin metabolism pathway associated with cucumber fruit skin color
M Wang, L Chen, Z Liang, X He, W Liu, B Jiang, J Yan… - BMC plant biology, 2020 - Springer
Background Fruit skin color play important role in commercial value of cucumber, which is
mainly determined by the content and composition of chlorophyll and anthocyanins …
mainly determined by the content and composition of chlorophyll and anthocyanins …
A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction
T Sato, S Verma, CDC Andrade, M Omeara… - Nature …, 2020 - nature.com
Osteocytes, cells ensconced within mineralized bone matrix, are the primary skeletal
mechanosensors. Osteocytes sense mechanical cues by changes in fluid flow shear stress …
mechanosensors. Osteocytes sense mechanical cues by changes in fluid flow shear stress …
Comparative analysis of novel MGISEQ-2000 sequencing platform vs Illumina HiSeq 2500 for whole-genome sequencing
The MGISEQ-2000 developed by MGI Tech Co. Ltd.(a subsidiary of the BGI Group) is a new
competitor of such next-generation sequencing platforms as NovaSeq and HiSeq (Illumina) …
competitor of such next-generation sequencing platforms as NovaSeq and HiSeq (Illumina) …
Characterization of a toxin-antitoxin system in Mycobacterium tuberculosis suggests neutralization by phosphorylation as the antitoxicity mechanism
X Yu, X Gao, K Zhu, H Yin, X Mao, JA Wojdyla… - Communications …, 2020 - nature.com
Mycobacterium tuberculosis (Mtb) encodes an exceptionally large number of toxin-antitoxin
(TA) systems, supporting the hypothesis that TA systems are involved in pathogenesis. We …
(TA) systems, supporting the hypothesis that TA systems are involved in pathogenesis. We …
[HTML][HTML] Diagnostic value and clinical application of next-generation sequencing for infections in immunosuppressed patients with corticosteroid therapy
S Wang, J Ai, P Cui, Y Zhu, H Wu… - Annals of translational …, 2020 - ncbi.nlm.nih.gov
Background Next-generation sequencing (NGS) is a comprehensive approach for sequence-
based identification of pathogens. However, reports on the use of NGS in patients with …
based identification of pathogens. However, reports on the use of NGS in patients with …
Serum PIWI-interacting RNAs piR-020619 and piR-020450 are promising novel biomarkers for early detection of colorectal cancer
Z Wang, H Yang, D Ma, Y Mu, X Tan, Q Hao… - … Biomarkers & Prevention, 2020 - AACR
Background: Early diagnosis can significantly reduce colorectal cancer deaths. We sought to
identify serum PIWI-interacting RNAs (piRNAs) that could serve as sensitive and specific …
identify serum PIWI-interacting RNAs (piRNAs) that could serve as sensitive and specific …
Comparative performance of the BGI and Illumina sequencing technology for single-cell RNA-sequencing
A Senabouth, S Andersen, Q Shi, L Shi… - NAR genomics and …, 2020 - academic.oup.com
The libraries generated by high-throughput single cell RNA-sequencing (scRNA-seq)
platforms such as the Chromium from 10× Genomics require considerable amounts of …
platforms such as the Chromium from 10× Genomics require considerable amounts of …
miRSwitch: detecting microRNA arm shift and switch events
Arm selection, the preferential expression of a 3′ or 5′ mature microRNA (miRNA), is a
highly dynamic and tissue-specific process. Time-dependent expression shifts or switches …
highly dynamic and tissue-specific process. Time-dependent expression shifts or switches …