Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-
dependent dementia. There is currently no effective treatment for AD, which may be …

Genes play a strong role in Alzheimer's disease (AD), with late-onset AD showing heritability
of 58–79% and early-onset AD showing over 90%. Genetic association provides a robust …

Our understanding of Alzheimer's disease (AD) pathophysiology remains incomplete. Here
we used quantitative mass spectrometry and coexpression network analysis to conduct the …

The Genotype-Tissue Expression (GTEx) project was established to characterize genetic
effects on the transcriptome across human tissues and to link these regulatory mechanisms …

Genome-wide association studies of neurological diseases have identified thousands of
variants associated with disease phenotypes. However, most of these variants do not alter …

Protein aggregation is the hallmark of neurodegeneration, but the molecular mechanisms
underlying late-onset Alzheimer's disease (AD) are unclear. Here we integrated …

The discovery of TREM2 as a myeloid-specific Alzheimer's disease (AD) risk gene has
accelerated research into the role of microglia in AD. While TREM2 mouse models have …

The brain is a site of relative immune privilege. Although CD4 T cells have been reported in
the central nervous system, their presence in the healthy brain remains controversial, and …

A wide range of proteins have been reported to condensate into a dense liquid phase,
forming a reversible droplet state. Failure in the control of the droplet state can lead to the …

Single-nucleus RNA sequencing (snRNA-seq) is used as an alternative to single-cell RNA-
seq, as it allows transcriptomic profiling of frozen tissue. However, it is unclear whether …