Genes play a strong role in Alzheimer's disease (AD), with late-onset AD showing heritability
of 58–79% and early-onset AD showing over 90%. Genetic association provides a robust …

Theme issue: Psoriasis loci. Despite the complex correlation structure across the MHC due
to extensive linkage disequilibrium (Box 1)(16), HLA-C* 06: 02 is now confidently …

Objective: The 2-year risk of psychosis in persons who meet research criteria for a high-risk
syndrome is about 15%− 25%; improvements in risk prediction accuracy would benefit the …

Despite strong transethnic genetic correlations reported in the literature for many complex
traits, the non-transferability of polygenic risk scores across populations suggests the …

While genome-wide association studies have identified susceptibility variants for numerous
traits, their combined utility for predicting broad measures of health, such as mortality …

To date, interpretation of genomic information has focused on single variants conferring
disease risk, but most disorders of major public concern have a polygenic architecture …

Objective Observational studies point to an inverse correlation between low‐density
lipoprotein (LDL) cholesterol levels and risk of intracerebral hemorrhage (ICH), but it …

Genetic risk prediction is an important problem in human genetics, and accurate prediction
can facilitate disease prevention and treatment. Calculating polygenic risk score (PRS) has …

Sepsis is a series of clinical syndromes caused by the immunological response to infection.
The clinical evidence for sepsis could typically attribute to bacterial infection or bacterial …

Abstract Treatment-resistant depression (TRD) occurs in~ 30% of patients with major
depressive disorder (MDD) but the genetics of TRD was previously poorly investigated …