Advances in single-cell technologies have enabled the investigation of T-cell phenotypes
and repertoires at unprecedented resolution and scale. Bioinformatic methods for the …

Lymphocytes play a critical role in antitumor immune responses. They are directly targeted
by some therapies, and the composition and spatial organization of intratumor T-cell …

The human antibody repertoire is generated by the recombination of different gene
segments as well as by processes of somatic mutation. Together these mechanisms result in …

Antibody repertoires reveal insights into the biology of the adaptive immune system and
empower diagnostics and therapeutics. There are currently multiple tools available for the …

Adaptive immune receptor repertoire sequencing (AIRR-Seq) offers the possibility of
identifying and tracking B cell clonal expansions during adaptive immune responses …

The Adaptive Immune Receptor Repertoire (AIRR) Community is a research-driven group
that is establishing a clear set of community-accepted data and metadata standards; …

We previously showed, in a pilot study with publicly available data, that T cell receptor (TCR)
repertoires from tumor infiltrating lymphocytes (TILs) could be distinguished from adjacent …

One of the remaining challenges to describing an individual's genetic variation lies in the
highly heterogeneous and complex genomic regions that impede the use of classical …

Abstract Systems biology involves network-oriented, computational approaches to modeling
biological systems through analysis of big biological data. To contribute maximally to …

Data holds the potential to drive rapid response and informed decision-making during public
health emergencies. There is a need for timely and accurate collection, reporting and …