Flavonoids as natural phenolic compounds and their role in therapeutics: An overview

RE Mutha, AU Tatiya, SJ Surana - Future journal of pharmaceutical …, 2021 - Springer
Background Natural plants and plant-derived formulations have been used by mankind from
the ancient period of time. For the past few years, many investigations elaborated the …

Natural product-based nanoformulations for cancer therapy: Opportunities and challenges

D Kashyap, HS Tuli, MB Yerer, A Sharma, K Sak… - Seminars in cancer …, 2021 - Elsevier
Application of natural product-based nanoformulations for the treatment of different human
diseases, such as cancer, is an emerging field. The conventional cancer therapeutic …

Food flavonols: Nutraceuticals with complex health benefits and functionalities

D Barreca, D Trombetta, A Smeriglio… - Trends in food science & …, 2021 - Elsevier
Background Flavonols are one of the most promising class of bioactive compounds
belonging to the broad family of the flavonoids, characterized by a unique set of features in …

[HTML][HTML] Does oral apigenin have real potential for a therapeutic effect in the context of human gastrointestinal and other cancers?

EF DeRango-Adem, J Blay - Frontiers in pharmacology, 2021 - frontiersin.org
Apigenin (4′, 5, 7-trihydroxyflavone) is a plant flavone that has been found to have various
actions against cancer cells. We evaluated available evidence to determine whether it is …

Apigenin induces autophagy and cell death by targeting EZH2 under hypoxia conditions in gastric cancer cells

TW Kim, HG Lee - International Journal of Molecular Sciences, 2021 - mdpi.com
Hypoxia is a major obstacle to gastric cancer (GC) therapy and leads to chemoresistance as
GC cells are frequently exposed to the hypoxia environment. Apigenin, a flavonoid found in …

Metabolomics and Molecular Networking to Characterize the Chemical Space of Four Momordica Plant Species

AT Ramabulana, D Petras, NE Madala, F Tugizimana - Metabolites, 2021 - mdpi.com
Momordica plant species (Cucurbitaceae), have been used for centuries in traditional
medicine and for nutritional purposes. Plants from this family are thus claimed to be …

Extraction of chlorophyll and carotenoids loaded into chitosan as potential targeted therapy and bio imaging agents for breast carcinoma

NAN Hanafy, S Leporatti, MA El-Kemary - International journal of biological …, 2021 - Elsevier
In the current study, the treatment efficacy of ECHCAH was evaluated in vitro studies using
cell viability and flow cytometry in human TNBCs. The results here showed significant …

Co-delivery of quercetin and caffeic-acid phenethyl ester by polymeric nanoparticles for improved antitumor efficacy in colon cancer cells

RD Colpan, A Erdemir - Journal of Microencapsulation, 2021 - Taylor & Francis
Aim This study aimed to synthesise quercetin-caffeic-acid phenethyl ester (CAPE)-co-loaded
poly (lactic-co-glycolic-acid)(PLGA) nanoparticles (QuCaNP) and investigate their anti …

Cogent role of flavonoids as key orchestrators of chemoprevention of hepatocellular carcinoma: A review

J Baby, AR Devan, AR Kumar… - Journal of Food …, 2021 - Wiley Online Library
Chemopreventive approaches with food‐derived phytochemicals are progressively rising as
a significant aspect of tumor management and control. Herein, we have showcased the …

Therapeutic potential of glycosyl flavonoids as anti-coronaviral agents

PIC Godinho, RG Soengas, VLM Silva - Pharmaceuticals, 2021 - mdpi.com
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), has spread all over the world, creating a devastating socio-economic impact …