A plethora of studies indicate that iron metabolism is dysregulated in Parkinson's disease
(PD). The literature reveals well-documented alterations consistent with established dogma …

Accumulation of the neuronal presynaptic protein alpha-synuclein within proteinaceous
inclusions represents the key histophathological hallmark of a spectrum of …

Parkinson's disease (PD) is a movement disorder attributed to the loss of dopaminergic (DA)
neurons mainly in the substantia nigra pars compacta. Motor symptoms include resting …

A change in microglia structure, signaling, or function is commonly associated with
neurodegeneration. This is evident in the patient population, animal models, and targeted in …

The reason why dopamine neurons die in Parkinson's disease remains largely unknown.
Emerging evidence points to a role for brain inflammation in neurodegeneration. Essential …

Although β-arrestins (ARRBs) regulate diverse physiological and pathophysiological
processes, their functions and regulation in Parkinson's disease (PD) remain poorly defined …

Alpha-synuclein accumulation in dopaminergic neurons is one of the primary features of
Parkinson's disease (PD). Despite its toxic properties during PD, alpha-synuclein has some …

Iron loading in some brain regions occurs in Parkinson's Disease (PD), and it has been
considered that its removal by iron chelators could be an appropriate therapeutic approach …

Exposure to environmental toxicants is prevalent, hazardous and linked to varied
detrimental health outcomes and disease. Polychlorinated biphenyls (PCBs), a class of …

Parkinson's disease is a multifaceted neurodegenerative disorder that currently has no cure.
Chronic neuroinflammation is thought to play a crucial role in the progression of the disease …