GrimAge outperforms other epigenetic clocks in the prediction of age-related clinical phenotypes and all-cause mortality
The aging process is characterized by the presence of high interindividual variation between
individuals of the same chronical age prompting a search for biomarkers that capture this …
individuals of the same chronical age prompting a search for biomarkers that capture this …
How are social determinants of health integrated into epigenetic research? A systematic review
Objective We systematically review the literature on social epigenetics, examining how
empirical research to date has conceptualized and operationalized social determinants of …
empirical research to date has conceptualized and operationalized social determinants of …
DNA methylation‐based biomarkers of aging were slowed down in a two‐year diet and physical activity intervention trial: the DAMA study
Several biomarkers of healthy aging have been proposed in recent years, including the
epigenetic clocks, based on DNA methylation (DNAm) measures, which are getting …
epigenetic clocks, based on DNA methylation (DNAm) measures, which are getting …
Perinatal stress and epigenetics
M Szyf - Handbook of clinical neurology, 2021 - Elsevier
Animal and humans exposed to stress early in life are more likely to suffer from long-term
behavioral, mental health, metabolic, immune, and cardiovascular health consequences …
behavioral, mental health, metabolic, immune, and cardiovascular health consequences …
Systemic racism can get under our skin and into our genes
CJ Mulligan - American Journal of Physical Anthropology, 2021 - Wiley Online Library
Can traumatic experiences affect our genes, and can the effects be passed on to future
generations? There is strong scientific evidence indicating that the impact of trauma can …
generations? There is strong scientific evidence indicating that the impact of trauma can …
Alcohol consumption is associated with widespread changes in blood DNA methylation: analysis of cross‐sectional and longitudinal data
DNA methylation may be one of the mechanisms by which alcohol consumption is
associated with the risk of disease. We conducted a large‐scale, cross‐sectional, genome …
associated with the risk of disease. We conducted a large‐scale, cross‐sectional, genome …
Toward a framework for assessing privacy risks in multi-omic research and databases
C Dupras, EM Bunnik - The American Journal of Bioethics, 2021 - Taylor & Francis
While the accumulation and increased circulation of genomic data have captured much
attention over the past decade, privacy risks raised by the diversification and integration of …
attention over the past decade, privacy risks raised by the diversification and integration of …
Genome-Wide DNA methylation analysis of a cohort of 41 patients affected by oculo-auriculo-vertebral spectrum (OAVS)
V Guida, L Calzari, MT Fadda… - International Journal of …, 2021 - mdpi.com
Oculo-auriculo-vertebral-spectrum (OAVS; OMIM 164210) is a rare disorder originating from
abnormal development of the first and second branchial arch. The clinical phenotype is …
abnormal development of the first and second branchial arch. The clinical phenotype is …
Dietary polyphenol intake is associated with biological aging, a novel predictor of cardiovascular disease: cross-sectional findings from the moli-sani study
Biological aging, or the discrepancy between biological and chronological age of a subject
(Δage), has been associated with a polyphenol-rich Mediterranean diet and represents a …
(Δage), has been associated with a polyphenol-rich Mediterranean diet and represents a …
Multiomic biological approaches to the study of child abuse and neglect
SD Layfield, LA Duffy, KA Phillips, R Lardenoije… - Pharmacology …, 2021 - Elsevier
Childhood maltreatment, occurring in up to 20-30% of the population, remains far too
common, and incorporates a range of active and passive factors, from abuse, to neglect, to …
common, and incorporates a range of active and passive factors, from abuse, to neglect, to …