Tissue mechanics in stem cell fate, development, and cancer

MK Hayward, JM Muncie, VM Weaver - Developmental cell, 2021 - cell.com
Cells in tissues experience a plethora of forces that regulate their fate and modulate
development and homeostasis. Cells sense mechanical cues through localized …

Mechanotransduction at the plasma membrane-cytoskeleton interface

IP Uray, K Uray - International journal of molecular sciences, 2021 - mdpi.com
Mechanical cues are crucial for survival, adaptation, and normal homeostasis in virtually
every cell type. The transduction of mechanical messages into intracellular biochemical …

Volumetric compression induces intracellular crowding to control intestinal organoid growth via Wnt/β-catenin signaling

Y Li, M Chen, J Hu, R Sheng, Q Lin, X He, M Guo - Cell stem cell, 2021 - cell.com
Enormous amounts of essential intracellular events are crowdedly packed inside picoliter-
sized cellular space. However, the significance of the physical properties of cells remains …

Viscoelasticity acts as a marker for tumor extracellular matrix characteristics

CT Mierke - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
Biological materials such as extracellular matrix scaffolds, cancer cells, and tissues are often
assumed to respond elastically for simplicity; the viscoelastic response is quite commonly …

Stiffness increases with myofibroblast content and collagen density in mesenchymal high grade serous ovarian cancer

V Mieulet, C Garnier, Y Kieffer, T Guilbert, F Nemati… - Scientific reports, 2021 - nature.com
Women diagnosed with high-grade serous ovarian cancers (HGSOC) are still likely to
exhibit a bad prognosis, particularly when suffering from HGSOC of the Mesenchymal …

Aberrant spinal mechanical loading stress triggers intervertebral disc degeneration by inducing pyroptosis and nerve ingrowth

F Fu, R Bao, S Yao, C Zhou, H Luo, Z Zhang… - Scientific reports, 2021 - nature.com
Aberrant mechanical factor is one of the etiologies of the intervertebral disc (IVD)
degeneration (IVDD). However, the exact molecular mechanism of spinal mechanical …

Apoptosis–Fueling the oncogenic fire

C Castillo Ferrer, K Berthenet, G Ichim - The FEBS journal, 2021 - Wiley Online Library
Apoptosis, the most extensively studied form of programmed cell death, is essential for
organismal homeostasis. Apoptotic cell death has widely been reported as a tumor …

Wnt/β-catenin signaling pathway in uterine leiomyoma: role in tumor biology and targeting opportunities

M El Sabeh, SK Saha, S Afrin, MS Islam… - Molecular and cellular …, 2021 - Springer
Uterine leiomyoma is the most common tumor of the female reproductive system and
originates from a single transformed myometrial smooth muscle cell. Despite the immense …

The frontier of live tissue imaging across space and time

Q Huang, A Garrett, S Bose, S Blocker, AC Rios… - Cell Stem Cell, 2021 - cell.com
What you see is what you get—imaging techniques have long been essential for
visualization and understanding of tissue development, homeostasis, and regeneration …

Mechanotransduction in gastrointestinal smooth muscle cells: role of mechanosensitive ion channels

V Joshi, PR Strege, G Farrugia… - American Journal of …, 2021 - journals.physiology.org
Mechanosensation, the ability to properly sense mechanical stimuli and transduce them into
physiologic responses, is an essential determinant of gastrointestinal (GI) function …