The prevalence of type 2 diabetes and obesity has risen dramatically for decades and is
expected to rise further, secondary to the growing aging, sedentary population. The strain on …

Context Type 2 diabetes mellitus (T2DM) and cancer share a variety of risk factors and
pathophysiological features. It is becoming increasingly accepted that the 2 diseases are …

Introduction There are known disparities in diabetes complications by race and ethnicity.
Although diabetes subgroups may contribute to differential risk, little is known about how …

OBJECTIVE We reevaluated the Action for Health in Diabetes (Look AHEAD) intervention,
incorporating diabetes subgroups, to identify whether intensive lifestyle intervention (ILI) is …

The pathogenesis of type 2 diabetes (T2D) might change with increasing age. Here, we
used a stratification based on age of diagnosis to gain insight into the genetics and causal …

In pancreatic β-cells, the expression of the splicing factor SRSF6 is regulated by GLIS3, a
transcription factor encoded by a diabetes susceptibility gene. SRSF6 down-regulation …

OBJECTIVE Current type 2 diabetes (T2D) management contraindicates intensive glycemia
treatment in patients with high cardiovascular disease (CVD) risk and is partially motivated …

Context Accumulating evidence indicates that type 2 diabetes (T2D) is phenotypically
heterogeneous. Defining and classifying variant forms of T2D are priorities to better …

Hundreds of common genetic variants acting through distinguishable physiologic pathways
influence the risk of type 2 diabetes (T2D). It is unknown to what extent the physiology …

OBJECTIVE The metabolic phenotype of youth-onset type 2 diabetes (T2D) differs from that
of adult-onset T2D, but little is known about genetic contributions. We aimed to evaluate the …