A variety of targeted nanoparticles were developed for the diagnosis and therapy of
orthotopic and metastatic bone tumors during the past decade. This critical review will focus …

Advances in the design of potential bone‐selective drugs for the treatment of various bone‐
related diseases are creating exciting new directions for multiple unmet medical needs. For …

Osteoporosis is one of the most common diseases affecting bone metabolism. Nitric oxide
(NO), an endogenous gas molecule involved in osteogenesis, can effectively promote the …

Multiple myeloma (MM) is a second ranking hematological malignancy. Despite the fast
advancement of new treatments such as bortezormib and daratumumab, MM patients …

We present a bone-targeting polymer vesicle with excellent single photon emission
computed tomography/computed tomography (SPECT/CT) imaging capability and high …

Ex vivo gene editing of CD34+ hematopoietic stem and progenitor cells (HSPCs) offers great
opportunities to develop new treatments for a number of malignant and non-malignant …

Metastatic tumors present great challenges in diagnosis and treatment. Herein, a proof-of-
concept theranostic nanoplatform composed of an Au nanoparticle core and a double-shell …

Bone targeting is one of the most potentially valuable therapeutic methods for medically
treating bone diseases, such as osteoarthritis, osteoporosis, nonunion bone defects, bone …

Extracellular adenosine has been shown to play a key role in maintaining bone health and
could potentially be used to treat bone loss. However, systemic administration of exogenous …

Hematological malignancies (HMs) typically persisting in the blood, lymphoma, and/or bone
marrow invalidate surgery and local treatments clinically used for solid tumors. The …