Interaction between coronavirus S-protein and human ACE2: hints for exploring efficient therapeutic targets to treat COVID-19

AA Momtazi-Borojeni, M Banach, Ž Reiner… - …, 2021 - journals.sagepub.com
With the global expansion of coronavirus disease 2019 (COVID-19) and the declaration of
its outbreak as a Public Health Emergency of International Concern by the World Health …

Immune response to COVID-19 infection: a double-edged sword

N Saad, S Moussa - Immunological medicine, 2021 - Taylor & Francis
COVID-19 global pandemic has not ceased to spread worldwide since December 2019.
Today, scientists and healthcare workers are urgently working to stop this viral invasion and …

[HTML][HTML] Common genetic variants and pathways in diabetes and associated complications and vulnerability of populations with different ethnic origins

SS Shoily, T Ahsan, K Fatema, AA Sajib - Scientific Reports, 2021 - nature.com
Diabetes mellitus is a complex and heterogeneous metabolic disorder which is often pre-or
post-existent with complications such as cardiovascular disease, hypertension …

[PDF][PDF] Linkage of blood pressure, obesity and diabetes mellitus with angiotensinogen gene (AGT 704T> C/rs699) polymorphism in hypertensive patients.

Y Repchuk, LP Sydorchuk, AR Sydorchuk… - Bratislava Medical …, 2021 - researchgate.net
ABSTRACT AIMS: The study aim was to analyse the frequency of polymorphic variants of
angiotensinogen gene polymorphism (AGT 704T> C, rs699) in essential arterial …

Role of autophagy and evaluation the effects of microRNAs 214, 132, 34c and prorenin receptor in a rat model of focal segmental glomerulosclerosis

D Yildirim, O Bender, ZF Karagoz, F Helvacioglu… - Life Sciences, 2021 - Elsevier
Aims Focal segmental glomerulosclerosis (FSGS) is the common cause of chronic renal
disease worldwide. Although there are many etiologic factors which have common theme of …

[HTML][HTML] Angiotensinogen gene missense polymorphisms (rs699 and rs4762): The association of end-stage renal failure risk with type 2 diabetes and hypertension in …

IM El-Garawani, EM Shaheen, HR El-Seedi… - Genes, 2021 - mdpi.com
Type 2 diabetes mellitus (T2DM) and hypertension are common chronic diseases mainly
associated with the development and progression of end-stage renal disease (ESRD) …

[HTML][HTML] A signaling pathway-driven bioinformatics pipeline for predicting therapeutics against emerging infectious diseases

TM Scott, S Jensen, BE Pickett - F1000Research, 2021 - ncbi.nlm.nih.gov
Background: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the
etiological agent of coronavirus disease-2019 (COVID-19), is a novel Betacoronavirus that …

Review of pharmacologic and immunologic agents in the management of COVID-19

MA Ungogo, M Mohammed, BN Umar, AA Bala… - Biosafety and …, 2021 - mednexus.org
The novel coronavirus disease 2019 (COVID-19) is the third coronavirus outbreak in the last
two decades. Emerging and re-emerging infections like COVID-19 pose serious challenges …

Dual blockade of the renin-angiotensin system: a strategy that should be reconsidered in cardiorenal diseases?

M Mei, Z Zhou, Q Zhang, Y Chen, H Zhao, B Shen - Nephron, 2021 - karger.com
Studies on pharmacological mechanisms demonstrated that a strategy of dual renin-
angiotensin system (RAS) blockade may have a synergistic effect in the treatment of …

[HTML][HTML] Angiotensin-Converting Enzyme 2 (ACE2) in the Context of Respiratory Diseases and Its Importance in Severe Acute Respiratory Syndrome Coronavirus 2 …

E Ambrocio-Ortiz, G Pérez-Rubio, AD Del Angel-Pablo… - Pharmaceuticals, 2021 - mdpi.com
Angiotensin-Converting Enzyme 2 (ACE2) is an 805 amino acid protein encoded by the
ACE2 gene expressed in various human cells, especially in those located in the epithelia …