Possible therapeutic potential of cysteinyl leukotriene receptor antagonist montelukast in treatment of SARS-CoV-2-induced COVID-19

M Dey, RK Singh - Pharmacology, 2021 - karger.com
Background: The coronavirus disease-19 (COVID-19) pandemic is a serious devastating
disease and has posed a global health emergency. So far, there is not any specific therapy …

Immune-mediated retinal vasculitis in posterior uveitis and experimental models: the leukotriene (LT) B4-VEGF axis

M Eskandarpour, MA Nunn, W Weston-Davies… - Cells, 2021 - mdpi.com
Retinal vascular diseases have distinct, complex and multifactorial pathogeneses yet share
several key pathophysiological aspects including inflammation, vascular permeability and …

Solidagenone from Solidago chilensis Meyen inhibits skin inflammation in experimental models

SS Valverde, BCS Santos… - Basic & Clinical …, 2021 - Wiley Online Library
Solidagenone (SOL) is a labdane‐type diterpenoid found in Solidago chilensis, a plant
traditionally used to treat skin diseases, kidney pain and ovarian inflammation. In this study …

Fractions of Boswellia serrata suppress LTA4, LTC4, cyclooxygenase-2 activities and mRNA in HL-60 cells and reduce lung inflammation in BALB/c mice

KK Soni, D Meshram, TO Lawal, U Patel… - Current drug …, 2021 - ingentaconnect.com
Background: Purified fractions from a Boswellia serrata Roxb. Ex. Colebr.(Burseraceae)
extract (ETOH and DCM) contain biologically active compounds that are well known for …

Structural basis for developing multitarget compounds acting on cysteinyl leukotriene receptor 1 and G-protein-coupled bile acid receptor 1

B Fiorillo, V Sepe, P Conflitti, R Roselli… - Journal of Medicinal …, 2021 - ACS Publications
G-protein-coupled receptors (GPCRs) are the molecular target of 40% of marketed drugs
and the most investigated structures to develop novel therapeutics. Different members of the …

5-lipoxygenase-and Glucocorticoid-dependent eosinophilia in a novel surgical model in mice

BM Vieira, CC de Souza, D Masid, RN Ferreira… - International …, 2021 - Elsevier
Background Subcutaneous implants of heat–coagulated egg white (egg white implants,
EWI) induce intense local eosinophilia and prime for hyperreactivity following airway …

Experimental Studies of Lipid Mediator Modulation of Airway Responsiveness

W Abma - 2021 - search.proquest.com
Lipid mediators play an important role in responsiveness of the airways. The roles of
prostanoids and leukotrienes in inducing airway inflammation and contraction are …

[PDF][PDF] ZAFIRLUKAST: CHRONOTHERAPEUTIC APPROACH AND DETAILED PHARMACEUTICAL REVIEW

P Bailpattar, KL Naveen, P Vijapur - 2021 - researchgate.net
Zafirlukast is one of promising medication used in the management and prophylactic
treatment of bronchial asthma. It's orally active, potent, selective and competitive cysteinyl …