Therapeutic targets in lung tissue remodelling and fibrosis
Structural changes involving tissue remodelling and fibrosis are major features of many
pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD) and …
pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD) and …
[HTML][HTML] Emerging concepts in PD-1 checkpoint biology
KE Pauken, JA Torchia, A Chaudhri, AH Sharpe… - Seminars in …, 2021 - Elsevier
The PD-1 pathway is a cornerstone in immune regulation. While the PD-1 pathway has
received considerable attention for its role in contributing to the maintenance of T cell …
received considerable attention for its role in contributing to the maintenance of T cell …
[HTML][HTML] The charming world of the extracellular matrix: a dynamic and protective network of the intestinal wall
The intestinal extracellular matrix (ECM) represents a complex network of proteins that not
only forms a support structure for resident cells but also interacts closely with them by …
only forms a support structure for resident cells but also interacts closely with them by …
[HTML][HTML] Origins, potency, and heterogeneity of skeletal muscle fibro-adipogenic progenitors—time for new definitions
Striated muscle is a highly plastic and regenerative organ that regulates body movement,
temperature, and metabolism—all the functions needed for an individual's health and well …
temperature, and metabolism—all the functions needed for an individual's health and well …
[HTML][HTML] Role and clinical significance of TGF‑β1 and TGF‑βR1 in malignant tumors
J Wang, H Xiang, Y Lu, T Wu - … journal of molecular …, 2021 - spandidos-publications.com
The appearance and growth of malignant tumors is a complicated process that is regulated
by a number of genes. In recent years, studies have revealed that the transforming growth …
by a number of genes. In recent years, studies have revealed that the transforming growth …
[HTML][HTML] Blood platelets as an important but underrated circulating source of TGFβ
K Karolczak, C Watala - International journal of molecular sciences, 2021 - mdpi.com
When treating diseases related primarily to tissue remodeling and fibrosis, it is desirable to
regulate TGFβ concentration and modulate its biological effects. The highest cellular …
regulate TGFβ concentration and modulate its biological effects. The highest cellular …
TGFβ family signaling and development
S Jia, A Meng - Development, 2021 - journals.biologists.com
The transforming growth factor β (TGFβ) signaling family is evolutionarily conserved in
metazoans. The signal transduction mechanisms of TGFβ family members have been …
metazoans. The signal transduction mechanisms of TGFβ family members have been …
A primer on cytokines
Cytokines are pleiotropic polypeptides that control the development of and responses
mediated by immune cells. Cytokine classification predominantly relies on [1] the target …
mediated by immune cells. Cytokine classification predominantly relies on [1] the target …
[HTML][HTML] Saracatinib is an efficacious clinical candidate for fibrodysplasia ossificans progressiva
E Williams, J Bagarova, G Kerr, DD Xia, ES Place… - Jci Insight, 2021 - ncbi.nlm.nih.gov
Currently, no effective therapies exist for fibrodysplasia ossificans progressiva (FOP), a rare
congenital syndrome in which heterotopic bone is formed in soft tissues owing to …
congenital syndrome in which heterotopic bone is formed in soft tissues owing to …
[HTML][HTML] The role of TGF-β2 in cartilage development and diseases
M Duan, Q Wang, Y Liu, J Xie - Bone & Joint Research, 2021 - boneandjoint.org.uk
Transforming growth factor-beta2 (TGF-β2) is recognized as a versatile cytokine that plays a
vital role in regulation of joint development, homeostasis, and diseases, but its role as a …
vital role in regulation of joint development, homeostasis, and diseases, but its role as a …