JAKs are intracellular protein tyrosine kinases that, through activation of STATs, are
responsible for signal transduction pathways that regulate cellular responses to numerous …

Systemic sclerosis (SSc) is a complex disease, in which an interaction of genetic and
environmental factors plays an important role in its development and pathogenesis. A …

Age is a common risk factor in many diseases, but the molecular basis for this relationship is
elusive. In this study we identified four disease clusters from 116 diseases in UK Biobank …

Aims/hypothesis Prognostic factors and characteristics of children diagnosed with type 1
diabetes before 6 years of age were compared with those diagnosed at 6–13 years of age in …

Genetic correlations between traits may cause correlated responses to selection. Previous
models described the conditions under which genetic correlations are expected to be …

Celiac disease (CD) is an immune-mediated enteropathy caused by gluten ingestion,
affecting approximately 1% of the worldwide population. Extraintestinal symptoms may be …

This post hoc analysis of the UNITI studies found ustekinumab (UST) did not significantly
improve overall extraintestinal manifestations (EIMs) of Crohn's disease compared to …

Objectives Genomic Risk Scores (GRS) successfully demonstrated the ability of genetics to
identify those individuals at high risk for complex traits including immune-mediated …

Spondyloarthritis (SpA) encompasses a group of disorders characterized by presence of
enthesitis, axial skeletal involvement and a common genetic predisposition most notably …

Background Systems biology is a rapidly advancing field of science that allows us to look
into disease mechanisms, patient diagnosis and stratification, and drug development in a …