Interfacing living and synthetic cells as an emerging frontier in synthetic biology

Y Elani - Angewandte Chemie, 2021 - Wiley Online Library
The construction of artificial cells from inanimate molecular building blocks is one of the
grand challenges of our time. In addition to being used as simplified cell models to decipher …

Can bottom-up synthetic biology generate advanced drug-delivery systems?

F Lussier, O Staufer, I Platzman, JP Spatz - Trends in Biotechnology, 2021 - cell.com
Creating a magic bullet that can selectively kill cancer cells while sparing nearby healthy
cells remains one of the most ambitious objectives in pharmacology. Nanomedicine, which …

A Biocatalytic Cascade in an Ultrastable Mesoporous Hydrogen‐Bonded Organic Framework for Point‐of‐Care Biosensing

Z Tang, X Li, L Tong, H Yang, J Wu… - Angewandte Chemie …, 2021 - Wiley Online Library
Herein, we report the first example of using mesoporous hydrogen‐bonded organic
frameworks (MHOFs) as the protecting scaffold to organize a biocatalytic cascade. The …

Membranization of coacervates into artificial phagocytes with predation toward bacteria

C Zhao, J Li, S Wang, Z Xu, X Wang, X Liu, L Wang… - ACS …, 2021 - ACS Publications
Coacervate-based membraneless organelles with diverse functionality as well as the
capability of mimicking intracellular physiological environments are attracting researchers' …

Design and construction of novel biocatalyst for bioprocessing: Recent advances and future outlook

Y Xu, Y Wu, X Lv, G Sun, H Zhang, T Chen, G Du… - Bioresource …, 2021 - Elsevier
Bioprocess, a biocatalysis-based technology, is becoming popular in many research fields
and widely applied in industrial manufacturing. However, low bioconversion, low …

Lipid vesicles and other polymolecular aggregates—from basic studies of polar lipids to innovative applications

P Walde, S Ichikawa - Applied Sciences, 2021 - mdpi.com
Lipid vesicles (liposomes) are a unique and fascinating type of polymolecular aggregates,
obtained from bilayer-forming amphiphiles—or mixtures of amphiphiles—in an aqueous …

A modular, dynamic, DNA-based platform for regulating cargo distribution and transport between lipid domains

R Rubio-Sánchez, SE Barker, M Walczak, P Cicuta… - Nano Letters, 2021 - ACS Publications
Cell membranes regulate the distribution of biological machinery between phase-separated
lipid domains to facilitate key processes including signaling and transport, which are among …

Gold nanobeads with enhanced absorbance for improved sensitivity in competitive lateral flow immunoassays

X Chen, X Miao, T Ma, Y Leng, L Hao, H Duan, J Yuan… - Foods, 2021 - mdpi.com
Background: Colloidal gold based lateral flow immunoassay (LFIA) commonly suffers from
relatively low detection sensitivity due to the insufficient brightness of conventional gold …

Reversible Light‐Responsive Coacervate Microdroplets with Rapid Regulation of Enzymatic Reaction Rate

Y Huang, X Wang, J Li, Y Lin, H Chen, X Liu… - …, 2021 - Wiley Online Library
Membrane‐free coacervate microdroplets are widely utilized as protocell or membrane‐less
organelle models in the study of cell physicochemical properties. Dynamic regulation of …

Linear triglycerol-based fluorosurfactants show high potential for droplet-microfluidics-based biochemical assays

MS Chowdhury, W Zheng, AK Singh, ILH Ong, Y Hou… - Soft Matter, 2021 - pubs.rsc.org
Fluorosurfactants have expanded the landscape of high-value biochemical assays in
microfluidic droplets, but little is known about how the spatial geometries and polarity of the …