Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention
X Zhu, Z Chen, W Shen, G Huang, JM Sedivy… - Signal transduction and …, 2021 - nature.com
Remarkable progress in ageing research has been achieved over the past decades.
General perceptions and experimental evidence pinpoint that the decline of physical …
General perceptions and experimental evidence pinpoint that the decline of physical …
Sex differences in biological aging with a focus on human studies
S Hägg, J Jylhävä - Elife, 2021 - elifesciences.org
Aging is a complex biological process characterized by hallmark features accumulating over
the life course, shaping the individual's aging trajectory and subsequent disease risks. There …
the life course, shaping the individual's aging trajectory and subsequent disease risks. There …
GrimAge outperforms other epigenetic clocks in the prediction of age-related clinical phenotypes and all-cause mortality
The aging process is characterized by the presence of high interindividual variation between
individuals of the same chronical age prompting a search for biomarkers that capture this …
individuals of the same chronical age prompting a search for biomarkers that capture this …
Disparities in the pace of biological aging among midlife adults of the same chronological age have implications for future frailty risk and policy
Some humans age faster than others. Variation in biological aging can be measured in
midlife, but the implications of this variation are poorly understood. We tested associations …
midlife, but the implications of this variation are poorly understood. We tested associations …
Deep learning encodes robust discriminative neuroimaging representations to outperform standard machine learning
Recent critical commentaries unfavorably compare deep learning (DL) with standard
machine learning (SML) approaches for brain imaging data analysis. However, their …
machine learning (SML) approaches for brain imaging data analysis. However, their …
Epigenetic age prediction
DJ Simpson, T Chandra - Aging cell, 2021 - Wiley Online Library
Advanced age is the main common risk factor for cancer, cardiovascular disease and
neurodegeneration. Yet, more is known about the molecular basis of any of these groups of …
neurodegeneration. Yet, more is known about the molecular basis of any of these groups of …
DNA methylation predicts age and provides insight into exceptional longevity of bats
Exceptionally long-lived species, including many bats, rarely show overt signs of aging,
making it difficult to determine why species differ in lifespan. Here, we use DNA methylation …
making it difficult to determine why species differ in lifespan. Here, we use DNA methylation …
Cellular reprogramming and epigenetic rejuvenation
Ageing is an inevitable condition that afflicts all humans. Recent achievements, such as the
generation of induced pluripotent stem cells, have delivered preliminary evidence that …
generation of induced pluripotent stem cells, have delivered preliminary evidence that …
Brain-age in midlife is associated with accelerated biological aging and cognitive decline in a longitudinal birth cohort
ML Elliott, DW Belsky, AR Knodt, D Ireland… - Molecular …, 2021 - nature.com
An individual's brainAGE is the difference between chronological age and age predicted
from machine-learning models of brain-imaging data. BrainAGE has been proposed as a …
from machine-learning models of brain-imaging data. BrainAGE has been proposed as a …
Associations of age, sex, race/ethnicity, and education with 13 epigenetic clocks in a nationally representative US sample: the Health and Retirement Study
Background Many DNA methylation-based indicators have been developed as summary
measures of epigenetic aging. We examine the associations between 13 epigenetic clocks …
measures of epigenetic aging. We examine the associations between 13 epigenetic clocks …