The diagnostic value of metagenomic next–generation sequencing in lower respiratory tract infection

Y Zheng, X Qiu, T Wang, J Zhang - Frontiers in cellular and infection …, 2021 - frontiersin.org
Lower respiratory tract infections are associated with high morbidity and mortality and
significant clinical harm. Due to the limited ability of traditional pathogen detection methods …

[PDF][PDF] Community-acquired pneumonia: A focused review

JH Ticona, VM Zaccone… - Am J Med …, 2021 - article.americanmedicalcasereports …
Community-acquired pneumonia (CAP) is a common cause for admission to the hospital
and contributes significantly to patient morbidity and healthcare cost. We present a review of …

Determinants of acute respiratory infection among under-five children in rural Ethiopia

AM Merera - BMC infectious diseases, 2021 - Springer
Introduction In low-and middle-income nations, acute respiratory infection (ARI) is the
primary cause of morbidity and mortality. According to some studies, Ethiopia has a higher …

Virulence Characteristics of Biofilm-Forming Acinetobacter baumannii in Clinical Isolates Using a Galleria mellonella Model

MAF Khalil, FA Ahmed, AF Elkhateeb, EE Mahmoud… - Microorganisms, 2021 - mdpi.com
Acinetobacter baumannii is a Gram-negative coccobacillus responsible for severe hospital-
acquired infections, particularly in intensive care units (ICUs). The current study was …

Detection of viral and bacterial respiratory pathogens identified by molecular methods in COVID-19 hospitalized patients and its impact on mortality and unfavorable …

A Soto, DM Quiñones-Laveriano… - Infection and Drug …, 2021 - Taylor & Francis
Purpose The purpose of this study is to evaluate the frequency of viral and bacterial
respiratory pathogens detected by molecular methods in sputum samples of patients …

Microvesicles released from pneumolysin-stimulated lung epithelial cells carry mitochondrial cargo and suppress neutrophil oxidative burst

E Letsiou, LG Teixeira Alves, D Fatykhova, M Felten… - Scientific Reports, 2021 - nature.com
Microvesicles (MVs) are cell-derived extracellular vesicles that have emerged as markers
and mediators of acute lung injury (ALI). One of the most common pathogens in pneumonia …

[HTML][HTML] Gut microbiota and SCFAs play key roles in QingFei Yin recipe anti-streptococcal pneumonia effects

X Sun, D Wang, L Wei, L Ding, Y Guo… - Frontiers in cellular …, 2021 - frontiersin.org
Emerging evidence has revealed the presence in animals of a bidirectional regulatory “lung-
gut axis” that provides resistance to respiratory infections. Clues to the existence of this …

Development and evaluation of a nanopore 16S rRNA gene sequencing service for same day targeted treatment of bacterial respiratory infection in the intensive care …

R Baldan, PR Cliff, S Burns, A Medina, GC Smith… - Journal of Infection, 2021 - Elsevier
Objectives Assess the feasibility and impact of nanopore-based 16S rRNA gene sequencing
(Np16S) service on antibiotic treatment for acute severe pneumonia on the intensive care …

Antibacterial efficacy of some medicinal plants on multidrug resistance bacteria and their toxicity on eukaryotic cells

SMB Bataineh, YH Tarazi, WA Ahmad - Applied Sciences, 2021 - mdpi.com
The aim of this study was to evaluate the in vitro antimicrobial activity of medicinal
methanolic plant extracts against multidrug-resistant bacteria to determine the cytotoxicity of …

[HTML][HTML] Approach to identifying causative pathogens of community-acquired pneumonia in children using culture, molecular, and serology tests

Y Mardian, A Menur Naysilla, D Lokida, H Farida… - Frontiers in …, 2021 - frontiersin.org
Determining the causative pathogen (s) of community-acquired pneumonia (CAP) in
children remains a challenge despite advances in diagnostic methods. Currently available …