Stroke in Africa: profile, progress, prospects and priorities
Stroke is a leading cause of disability, dementia and death worldwide. Approximately 70% of
deaths from stroke and 87% of stroke-related disability occur in low-income and middle …
deaths from stroke and 87% of stroke-related disability occur in low-income and middle …
Migraine: disease characterisation, biomarkers, and precision medicine
M Ashina, GM Terwindt, MAM Al-Karagholi, I De Boer… - The Lancet, 2021 - thelancet.com
Migraine is a disabling neurological disorder, diagnosis of which is based on clinical criteria.
A shortcoming of these criteria is that they do not fully capture the heterogeneity of migraine …
A shortcoming of these criteria is that they do not fully capture the heterogeneity of migraine …
Development of polymeric nanoparticles for blood–brain barrier transfer—strategies and challenges
Neurological disorders such as Alzheimer's disease, stroke, and brain cancers are difficult to
treat with current drugs as their delivery efficacy to the brain is severely hampered by the …
treat with current drugs as their delivery efficacy to the brain is severely hampered by the …
[HTML][HTML] Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective …
Background COVID-19 is a multisystem disease and patients who survive might have in-
hospital complications. These complications are likely to have important short-term and long …
hospital complications. These complications are likely to have important short-term and long …
Disparities in the pace of biological aging among midlife adults of the same chronological age have implications for future frailty risk and policy
Some humans age faster than others. Variation in biological aging can be measured in
midlife, but the implications of this variation are poorly understood. We tested associations …
midlife, but the implications of this variation are poorly understood. We tested associations …
A blood-based diagnostic test incorporating plasma Aβ42/40 ratio, ApoE proteotype, and age accurately identifies brain amyloid status: findings from a multi cohort …
T West, KM Kirmess, MR Meyer, MS Holubasch… - Molecular …, 2021 - Springer
Background The development of blood-based biomarker tests that are accurate and robust
for Alzheimer's disease (AD) pathology have the potential to aid clinical diagnosis and …
for Alzheimer's disease (AD) pathology have the potential to aid clinical diagnosis and …
Hypertension: do inflammation and immunity hold the key to solving this epidemic?
Elevated cardiovascular risk including stroke, heart failure, and heart attack is present even
after normalization of blood pressure in patients with hypertension. Underlying immune cell …
after normalization of blood pressure in patients with hypertension. Underlying immune cell …
[HTML][HTML] Biofabrication of natural hydrogels for cardiac, neural, and bone Tissue engineering Applications
Natural hydrogels are one of the most promising biomaterials for tissue engineering
applications, due to their biocompatibility, biodegradability, and extracellular matrix …
applications, due to their biocompatibility, biodegradability, and extracellular matrix …
Selective targeting of the TLR2/MyD88/NF-κB pathway reduces α-synuclein spreading in vitro and in vivo
Pathways to control the spreading of α-synuclein (α-syn) and associated neuropathology in
Parkinson's disease (PD), multiple system atrophy (MSA) and dementia with Lewy bodies …
Parkinson's disease (PD), multiple system atrophy (MSA) and dementia with Lewy bodies …
Strategies for structural modification of small molecules to improve blood–brain barrier penetration: a recent perspective
B Xiong, Y Wang, Y Chen, S Xing, Q Liao… - Journal of Medicinal …, 2021 - ACS Publications
In the development of central nervous system (CNS) drugs, the blood–brain barrier (BBB)
restricts many drugs from entering the brain to exert therapeutic effects. Although many …
restricts many drugs from entering the brain to exert therapeutic effects. Although many …