Parkinson's disease (PD) is the second most common neurodegenerative disease
worldwide. Motor deficits usually associated with PD correlate with dopaminergic axonal …

Nearly all animal cells contain proteins evolved to trigger the destruction of the cell in which
they reside. The activation of these proteins occurs via sequential programs, and much effort …

Rationale: Coronavirus disease 2019 (COVID-19) is characterized by increased incidence
of microthrombosis with hyperactive platelets sporadically containing viral RNA. It is unclear …

Inflammaging, characterized by an increase in low‐grade chronic inflammation with age, is a
hallmark of aging and is strongly associated with various age‐related diseases, including …

Summary TANK binding kinase 1 (TBK1) regulates IFN-I, NF-κB, and TNF-induced RIPK1-
dependent cell death (RCD). In mice, biallelic loss of TBK1 is embryonically lethal. We …

Necroptosis is a caspase-independent, lytic form of programmed cell death whose errant
activation has been widely implicated in many pathologies. The pathway relies on the …

Necroptosis is a lytic, proinflammatory cell death pathway, which has been implicated in host
defense and, when dysregulated, the pathology of many human diseases. The central …

Mixed lineage kinase domain-like protein (MLKL) emerged as executioner of necroptosis, a
RIPK3-dependent form of regulated necrosis. Cell death evasion is one of the hallmarks of …

Necroptosis is a form of regulated necrosis mediated by the formation of the necrosome,
composed of the RIPK1/RIPK3/MLKL complex. Here, we developed a proximity ligation …

Necrosis, a type of unwanted and passive cell demise, usually occurs under the excessive
external stress and is considered to be unregulated. However, under some special …